Gigantol Suppresses Cancer Stem Cell-Like Phenotypes in Lung Cancer Cells

Evidence-based Complementary and Alternative Medicine : ECAM
Narumol Bhummaphan, Pithi Chanvorachote

Abstract

As cancer stem cells (CSCs) contribute to malignancy, metastasis, and relapse of cancers, potential of compound in inhibition of CSCs has garnered most attention in the cancer research as well as drug development fields recently. Herein, we have demonstrated for the first time that gigantol, a pure compound isolated from Dendrobium draconis, dramatically suppressed stem-like phenotypes of human lung cancer cells. Gigantol at nontoxic concentrations significantly reduced anchorage-independent growth and survival of the cancer cells. Importantly, gigantol significantly reduced the ability of the cancer cells to form tumor spheroids, a critical hallmark of CSCs. Concomitantly, the treatment of the compound was shown to reduce well-known lung CSCs markers, including CD133 and ALDH1A1. Moreover, we revealed that gigantol decreased stemness in the cancer cells by suppressing the activation of protein kinase B (Akt) signal which in turn decreased the cellular levels of pluripotency and self-renewal factors Oct4 and Nanog. In conclusion, gigantol possesses CSCs suppressing activity which may facilitate the development of this compound for therapeutic approaches by targeting CSCs.

References

May 1, 2001·Histochemistry and Cell Biology·C FoglieniA M Davalli
Dec 22, 2005·International Journal of Clinical Oncology·Takuhito TadaYuichi Inoue
Dec 21, 2006·Cell Research·Feng LiYibin Kang
Jan 6, 2007·International Journal of Cancer. Journal International Du Cancer·Yaser AtlasiAhmad-Reza Bahrami
Jul 25, 2007·Annual Review of Cell and Developmental Biology·Neethan A LoboMichael F Clarke
Oct 9, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Miten PatelJan S Moreb
Jan 1, 2009·Proceedings of the National Academy of Sciences of the United States of America·Anna DubrovskaVenkateshwar A Reddy
May 5, 2009·Stem Cells and Development·Yaojiong Wu, Philip Yuguang Wu
Nov 19, 2009·Toxicologic Pathology·Le ChengAlexander Yu Nikitin
Jan 16, 2010·Cell Death and Differentiation·S Mora-CastillaF J Bedoya
Mar 11, 2011·Cell Death & Disease·E M Abdelalim, I Tooyama
Mar 17, 2011·Journal of Asian Natural Products Research·Boonchoo SritularakKittisak Likhitwitayawuid
Mar 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Kathryn C DavidsonRandall T Moon
Apr 5, 2012·Nanomedicine·Serguei Vinogradov, Xin Wei
Apr 5, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Juanjuan ShanCheng Qian
Apr 25, 2012·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Takuya NagataKazuhiro Tsukada
Oct 23, 2012·Oncogene·J ZhangJ M Jessup
Oct 25, 2012·The Journal of Clinical Investigation·Kyung Hee NohTae Woo Kim
Nov 23, 2012·Journal of Ovarian Research·Chantel SamardzijaNuzhat Ahmed
Feb 20, 2013·Chinese Journal of Cancer·Anfei LiuShanrong Liu
Mar 13, 2013·International Journal of Clinical Oncology·Hidenori MizugakiMasaharu Nishimura
Mar 26, 2013·Clinical and Experimental Otorhinolaryngology·Tuba BayindirMahmut Tayyar Kalcioglu
Jun 8, 2013·Current Protocols in Pharmacology·Bin BaoFazlul H Sarkar
Sep 18, 2013·OncoTargets and Therapy·Mong-Lien WangCheng-Wen Wu
Dec 18, 2013·Biochemical and Biophysical Research Communications·Essam Mohamed Abdelalim, Ikuo Tooyama
May 23, 2014·Journal of Natural Products·Sopanya CharoenrungruangVarisa Pongrakhananon
Oct 17, 2014·Cell Death & Disease·M ZhuY Guo
Oct 17, 2014·International Journal of Molecular Sciences·Chuan-En HuangCheng-Chia Yu
Nov 12, 2014·Biotechnology and Applied Biochemistry·Kai-Hung WangTsung-Cheng Kuo
Nov 21, 2014·American Journal of Physiology. Cell Physiology·Nuttida YongsanguanchaiPithi Chanvorachote
Mar 11, 2015·Cell Reports·Panagiotis XenopoulosAnna-Katerina Hadjantonakis

❮ Previous
Next ❯

Citations

Sep 22, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Thitita UnahabhokhaVarisa Pongrakhananon
Feb 16, 2017·Applied Microbiology and Biotechnology·Jaime A Teixeira da Silva, Tzi Bun Ng
Apr 4, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Siyan ZhengYongping Cai
Aug 5, 2017·Chemistry & Biodiversity·Stefania SutStefano Dall'Acqua
Jun 7, 2020·Cancers·Maria Joana CatarataRui Medeiros
Sep 23, 2020·Journal of Cellular Physiology·Basira NajafzadehBehzad Baradaran
Jul 6, 2017·Cellular Oncology (Dordrecht)·Preeyaporn Plaimee Phiboonchaiyanan, Pithi Chanvorachote
Jan 7, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Thitita UnahabhokhaVarisa Pongrakhananon
Mar 6, 2017·International Journal of Oncology·Songpol SrinualVarisa Pongrakhananon
Feb 16, 2018·BMC Complementary and Alternative Medicine·Shubin YuDesheng Lu
Oct 8, 2019·The Journal of Pharmacy and Pharmacology·Piriya ChonsutWannarasmi Ketchart
Aug 6, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Pornchanok TaweecheepChatchai Chaotham
Jul 24, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jyoti SinghAbha Meena
Oct 12, 2021·Experimental and Therapeutic Medicine·Yuxing CaiBaozhong Ren

❮ Previous
Next ❯

Methods Mentioned

BETA
transfection
NMR
protein assay

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.