Gingers and Their Purified Components as Cancer Chemopreventative Agents

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
John F Lechner, Gary D Stoner

Abstract

Chemoprevention by ingested substituents is the process through which nutraceuticals and/or their bioactive components antagonize carcinogenesis. Carcinogenesis is the course of action whereby a normal cell is transformed into a neoplastic cell. This latter action involves several steps, starting with initiation and followed by promotion and progression. Driving these stages is continued oxidative stress and inflammation, which in turn, causes a myriad of aberrant gene expressions and mutations within the transforming cell population and abnormal gene expressions by the cells within the surrounding lesion. Chemoprevention of cancer with bioreactive foods or their extracted/purified components occurs primarily via normalizing these inappropriate gene activities. Various foods/agents have been shown to affect different gene expressions. In this review, we discuss how the chemoprevention activities of gingers antagonize cancer development.

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Citations

Apr 15, 2020·Journal of Complementary & Integrative Medicine·Kiptiyah KiptiyahSutiman B Sumitro
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Stanislav SukhikhOlga Babich
Jun 5, 2021·International Journal of Biological Macromolecules·Taurin HughesZulfiqar Ahmad
Jul 3, 2021·International Journal of Molecular Sciences·Mariia Zadorozhna, Domenica Mangieri

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