Gingival crevicular fluid monocyte chemoattractant protein-1 and RANTES levels in patients with generalized aggressive periodontitis

Journal of Clinical Periodontology
Gülnur EmingilAfig Hüseyinov

Abstract

Local and systemic inflammatory and immune mechanisms may be implicated in the pathogenesis of the aggressive forms of periodontal disease. Chemokines, monocyte chemoattractant protein-1 (MCP-1) and regulated on activation, normal T cells expressed and secreted RANTES (regulated on activation, normal T cells expressed and secreted), are involved in the activation and recruitment of inflammatory and immune cells to the infected sites and thereby mediating a variety of pathophysiological conditions. The aim of the present study was to examine the gingival crevicular fluid (GCF) levels of MCP-1 and RANTES in patients with generalized agressive periodontitis (G-AgP). MCP-1 and RANTES levels were investigated in GCF samples of 10 patients with G-AgP and 10 periodontally healthy subjects. Periodontal status was evaluated by measuring probing depth, clinical attachment loss, presence of bleeding on probing and plaque. In the G-AgP group, GCF samples were collected from the two approximal sites; from one single-rooted tooth and from one first molar tooth with > or =6 mm probing depth. In the healthy group, GCF samples were collected from one of the single-rooted teeth. GCF MCP-1 and RANTES levels were quantified by enzyme immunoassay. ...Continue Reading

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Citations

Aug 6, 2013·Molecular Oral Microbiology·S Amar, S Leeman
Jan 11, 2012·Clinical Microbiology Reviews·Brian M PetersMark E Shirtliff
Apr 6, 2006·Journal of Periodontology·Gülnur EmingilGül Atilla
Mar 12, 2010·Journal of Periodontology·Sema BecerikGülnur Emingil
Oct 12, 2010·Journal of Periodontology·Gülnur EmingilAlpdoğan Kantarci
Jun 17, 2008·Archives of Oral Biology·Daniel JönssonBengt-Olof Nilsson
Jul 7, 2005·Journal of Clinical Periodontology·Gülnur EmingilAfig Berdeli
Jul 6, 2006·Journal of Clinical Periodontology·Gülnur EmingilTimo Sorsa
Feb 20, 2007·Journal of Periodontal Research·L SavarrioT Berglundh
Oct 7, 2010·Journal of Diabetes·Abhijit Gurav, Varsha Jadhav
Jan 5, 2011·Journal of Clinical Periodontology·Keelen D TymkiwJanet M Guthmiller
Jan 14, 2011·Journal of Clinical Periodontology·Noriyoshi MizunoHidemi Kurihara
Aug 18, 2010·Periodontology 2000·Sami A ZelkhaSalomon Amar
Apr 17, 2013·Journal of Periodontal Research·T NiwaT Shibutani
Nov 13, 2014·Molecular Oral Microbiology·S Amar, M Engelke
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Sep 3, 2020·Journal of Clinical Periodontology·Jussara Gonçalves FernandesLuciana Macchion Shaddox
Nov 6, 2020·Clinical, Cosmetic and Investigational Dentistry·Maria K MakeevaAnna Yu Turkina
Apr 3, 2020·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Marko IgicAleksandra Milic Lemic

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