Gingival crevicular neutrophils: membrane molecules do not distinguish between periodontitis and gingivitis

Journal of Clinical Periodontology
B AsmanK Bergström

Abstract

We have earlier reported hyperreactive peripheral neutrophils in adult periodontitis, measured as respiratory burst after Fc gamma receptor-mediated activation in vitro, but we have not been able to relate this increased activity to aberrations in the expression of relevant membrane molecules. Various types of inflammatory conditions involving the gingiva should affect membranes differently. We therefore collected crevicular neutrophils from three types of inflammatory sites: (i) with and (ii) without tissue destruction in the same periodontitis patients and (iii) inflamed sites in controls with gingivitis alone and compared the expression of membrane molecules by flow cytometry. The % of positively stained cells and their mean intensities of fluorescence (IFL) were similar in the three types of sites for CD15, CD11a, CD11b and CD16. Peripheral neutrophils studied with the same markers were not activated. This was verified by similar plasma concentrations of lactoferrin and L-selectins in the periodontal and control groups. Compared to peripheral cells, the crevicular neutrophils showed a significantly lower percentage of stained cells, while the stained cells increased their IFL. In conclusion, hyperreactive peripheral neutrop...Continue Reading

References

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Citations

Jun 23, 1999·FEMS Immunology and Medical Microbiology·K B Bamford
Feb 13, 2010·Journal of Clinical Periodontology·Niki L DimouPantelis G Bagos
Aug 18, 2020·Journal of Periodontal Research·Nidhi MedaraIvan B Darby

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