Gingival epithelial barrier: regulation by beneficial and harmful microbes

Tissue Barriers
Naoki TakahashiKazuhisa Yamazaki

Abstract

The gingival epithelium acts as a physical barrier to separate the biofilm from the gingival tissue, providing the first line of defense against bacterial invasion in periodontal disease. Disruption of the gingival epithelial barrier, and the subsequent penetration of exogenous pathogens into the host tissues, triggers an inflammatory response, establishing chronic infection. Currently, more than 700 different bacterial species have been identified in the oral cavity, some of which are known to be periodontopathic. These bacteria contribute to epithelial barrier dysfunction in the gingiva by producing several virulence factors. However, some bacteria in the oral cavity appear to be beneficial, helping gingival epithelial cells maintain their integrity and barrier function. This review aims to discuss current findings regarding microorganism interactions and epithelial barrier function in the oral cavity, with reference to investigations in the gut, where this interaction has been extensively studied.

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Citations

May 12, 2020·Journal of Dental Research·S Ji, Y Choi
May 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Benso SulijayaKazuhisa Yamazaki
Apr 17, 2021·Journal of Immunology Research·Liang RenChengcheng Liu
Jul 14, 2021·Journal of Periodontal Research·Shaowen ZhengChen Li
Aug 8, 2021·International Journal of Molecular Sciences·Sevda Şenel

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