PMID: 9524320Apr 3, 1998Paper

Gingival fibroblast response to cyclosporin A and transforming growth factor beta 1

Journal of Periodontal Research
J A JamesG J Linden

Abstract

This study investigates a potential role for TGF beta 1 in the pathogenesis of cyclosporin A-induced gingival overgrowth (CsA-OG). TGF beta 1 was localized immunohistochemically in the connective tissue of both normal gingiva and CsA-OG. Intense staining for TGF beta 1 was detected at the tips of the dermal papillae of the overgrown gingiva. In addition, fibroblasts derived from healthy gingiva and fibroblasts derived from CsA-OG were cultured both as monolayers or embedded in a 3D-collagen gel. Fibroblast activity was monitored in terms of protein and collagen production in the presence of (i) 1 ng/ml TGF beta 1, (ii) 500 ng/ml CsA, or (iii) 500 ng/ml CsA and 1 ng/ml TGF beta 1. In monolayer culture TGF beta 1 significantly increased protein and collagen production in all cell strains (p < 0.05); however, there was no difference in response between fibroblasts from overgrown and healthy tissue. The production of both protein and collagen was significantly lower in the presence of the combination of CsA and TGF beta 1 when compared with the maximal stimulation produced by TGF beta 1 alone. In gel, TGF beta 1 significantly elevated matrix production by all overgrown cell strains (p < 0.05) but had little or no effect on the norm...Continue Reading

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Citations

May 16, 2003·Journal of Periodontology·Paula L HylandChris R Irwin
Feb 21, 2004·Journal of Periodontology·Nelson GnoattoMônica V Marquezini
Jun 10, 2004·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·P C Trackman, A Kantarci
Jun 18, 2004·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·G StabelliniE M Calvi
Mar 1, 2005·Journal of Periodontology·Omer Engin BulutSevda Müftüoğlu
Oct 25, 2007·Journal of Periodontal Research·N GnoattoM V Marquezini
Dec 7, 2007·Journal of Periodontology·Sule Bulut, B Handan Ozdemir
Sep 19, 2009·Clinical Rheumatology·Senol KobakEker Doganavsargil
Jan 29, 2016·Orphanet Journal of Rare Diseases·Katarzyna GawronMaria Chomyszyn-Gajewska
Sep 16, 2004·Journal of Clinical Periodontology·J S EllisJ M Thomason
Jul 11, 2006·Journal of Periodontal Research·J BirrauxJ J Taylor
Mar 22, 2008·Journal of Clinical Periodontology·Małgorzata Radwan-OczkoTadeusz Dobosz
Mar 9, 2000·Transplantation·D W ThomasG R Osborne
Aug 10, 2001·Journal of Periodontology·M I UzelP C Trackman
Feb 9, 2021·The Saudi Dental Journal·Azza A Abushama, AbdelRahman M Ramadan
Jun 9, 2004·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Nicoletta GaglianoMagda Gioia

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