Gingival overgrowth and dental alveolar alterations: possible mechanisms of cyclosporin-induced tooth migration. An experimental study in the rat

Journal of Periodontology
E FuE-C Shen

Abstract

The inter-incisal distance and dimension of the interdental papilla between the mandibular incisors were examined in cyclosporin A (CSA) fed rats over 6 weeks. Rats in the test group received CSA daily in mineral oil by gastric feeding (30 mg/kg body weight); the control group received mineral oil only. The inter-incisal distance and gingival dimensions, including bucco-lingual width and vertical height, were assessed biweekly from alginate impressed stone models. Animals were sacrificed at the end of the study and tissue sections were obtained from the anterior region of the mandible for histopathological evaluation. Both the inter-incisal distance and the dimension of the interdental papilla were significantly greater in CSA-exposed animals compared to control. The significant alteration appeared earlier in the papillary dimensions than that in the interdental distance. Particular histopathological alterations of the soft and hard tissues of the periodontium were observed in CSA-exposed animals. Within limitations of the study, we suggest that the CSA-induced gingival overgrowth may offer an active force contributing to observed tooth movement, however, remarkable alveolar remodeling should be considered as an undetermined fa...Continue Reading

References

Oct 1, 1992·Calcified Tissue International·L K McCauleyC C Capen
Apr 1, 1992·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·G P SchincagliaL del Senno
Jun 1, 1991·Journal of Cellular Biochemistry·D A TiptonM K Dabbous
Oct 1, 1991·Calcified Tissue International·M H ChowdhuryD W Dempster
Dec 1, 1991·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·T D DaleyA H Mamandras
Sep 1, 1990·Calcified Tissue International·S EpsteinF Ismail
Jan 1, 1990·Archives of Oral Biology·K KitamuraS Hamada
Oct 1, 1989·Calcified Tissue International·P J Stewart, P H Stern
Jul 1, 1989·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·V M ReznikS A Mendoza
May 1, 1986·Journal of Periodontology·M H RostockJ E Turner
Feb 1, 1986·Veterinary Immunology and Immunopathology·K S LatimerI M Kircher
Mar 1, 1983·Oral Surgery, Oral Medicine, and Oral Pathology·G P WysockiC R Stiller
May 1, 1983·Journal of Clinical Periodontology·E M Rateitschak-PlüssG Thiel
Nov 1, 1994·Journal of Periodontal Research·D A TiptonM K Dabbous
Jun 1, 1994·Journal of Periodontology·E J ZebrowskiR B Johnson
Mar 1, 1993·Journal of Cellular Biochemistry·D A Tipton, M K Dabbous
May 1, 1996·Journal of Periodontology·S NishikawaH Ishida

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Citations

Jun 17, 2000·Transplantation Proceedings·S BarakY Baruch
Oct 20, 2011·Orthodontics & Craniofacial Research·R Y ChenE Fu
Apr 2, 2002·Journal of Periodontology·Orit Oettinger-BarakMicha Peled
Jun 14, 2005·Journal of Periodontology·Michael A Brunsvold
Jun 8, 2001·Journal of Periodontology·J MirandaC Mendieta
Jun 8, 2001·Journal of Periodontology·E C ShenY D Hsieh
Apr 23, 2005·The Journal of Comparative Neurology·K Adam Baker, Ivar Mendez

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