PMID: 8957834Dec 1, 1995Paper

Gingival overgrowth in paediatric cardiac transplant patients: a study of 19 patients aged between 2 and 16 years

International Journal of Paediatric Dentistry
L Y LowryJ R Hamilton

Abstract

It is well established that both cyclosporin and nifedipine are associated with gingival overgrowth. However, there is little information on the prevalence of this undesirable effect in paediatric patients. The present study investigated gingival overgrowth in 19 cardiac transplant patients aged 2 years 8 months to 16 years 3 months (1.5-8.5 years post-transplant) and related such changes to variables of daily cyclosporin dosage, trough blood cyclosporin concentration and daily nifedipine dosage. Ten patients showed clinically significant gingival overgrowth and nine relatively minor overgrowth; there was no significant difference between the two groups with respect to age, length of time post-transplant, cyclosporin dosage, whole blood concentration of cyclosporin or intake of nifedipine. The expression of gingival changes therefore did not relate to any drug variable in this group of subjects.

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Citations

Jul 2, 2003·International Journal of Paediatric Dentistry·D ChabriaN M Kilpatrick
Feb 16, 2020·British Dental Journal·M O Gruter, H S Brand
Apr 16, 2005·Journal of Periodontology·Aikaterini DoufexiEffie Ioannidou
Mar 10, 2004·International Journal of Paediatric Dentistry·A Al NowaiserR S Trompeter
Aug 16, 2008·Journal of Periodontal Research·S De IudicibusF Bartoli
Aug 14, 2012·European Journal of Clinical Pharmacology·Montserrat GarcíaGuillermo Gervasini
Aug 1, 1997·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·R A SeymourA Nolan
Apr 1, 2006·Pediatric Transplantation·Franziska AnsariWilli-Eckhard Wetzel
Oct 22, 2005·International Journal of Paediatric Dentistry·G WrightM T Hosey
May 11, 2021·World Journal of Cardiology·Lucija BajkovecIvan Alajbeg
Dec 31, 2003·Transplantation Proceedings·H NowzariS Munroe

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