Gingival ulceration in HIV infection. A case series and case control study

Journal of Clinical Periodontology
P G RobinsonJ M Zakrzewska

Abstract

All cases of HIV-associated gingival ulceration seen at a dedicated dental clinic in a 5-year period were reviewed and compared against other patients attending the clinic. 94 (7.1%) of 1308 patients had 146 episodes of gingival ulceration. 89 patients had 140 episodes similar to acute necrotising ulcerative gingivitis (ANUG) and responded well to conventional treatment for ANUG. The cases were compared with 269 controls in logistic regression. Gingival ulceration was associated with oral candidiasis, lower age and lack of AIDS diagnosis possibly due to a protective effect of co-trimoxazole medication. 5 patients with neutropenia had extensive ulceration without the microflora of ANUG. Histopathology, viral and bacterial culture revealed non-specific changes. The ulcers did not respond to the treatment regimen for ANUG but responded to treatment of their neutropenia. Gingival ulceration is not common in HIV infection. Most cases resemble severe ANUG. It is more frequent in younger people, those with oral candidiasis and without AIDS. Co-trimoxazole may be protective. A minority of cases with ulceration and associated neutropenia resembled the non-specific oral ulceration associated with HIV.

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Citations

Aug 8, 2002·Oral Diseases·Peter G RobinsonN W Johnson
Oct 12, 2000·Sexually Transmitted Infections·I L Chapple, J Hamburger
Feb 16, 2010·Aging Clinical and Experimental Research·Silvia ChiandussiMatteo Biasotto
Sep 26, 2009·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Shikha TewariRajeev Sen
Dec 19, 2015·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Lauren L Patton
Aug 23, 2012·Periodontology 2000·Mark I RyderJohn S Greenspan
Jul 15, 2011·AIDS Research and Treatment·Neil Hamilton WoodLiviu Feller
Jan 14, 2004·Periodontology 2000·Esmonde F Corbet
May 5, 2006·Advances in Dental Research·M UmadeviP G Robinson
Aug 7, 2017·Internal Medicine·Hirofumi Kato, Akifumi Imamura
Dec 19, 2019·Periodontology 2000·Mark I RyderAnna-Barbara Moscicki
Apr 6, 2016·Periodontology 2000·Ellie T KnightMary P Cullinan
May 21, 2003·Periodontology 2000·Thomas W Stanford, Terry D Rees

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