Ginkgo biloba extract reduces high-glucose-induced endothelial adhesion by inhibiting the redox-dependent interleukin-6 pathways.

Cardiovascular Diabetology
Jia-Shiong ChenJaw-Wen Chen

Abstract

Chronic elevation of glucose level activates vascular inflammation and increases endothelial adhesiveness to monocytes, an early sign of atherogenesis. This study aimed to elucidate the detailed mechanisms of high-glucose-induced endothelial inflammation, and to investigate the potential effects of Ginkgo biloba extract (GBE), an antioxidant herbal medicine, on such inflammation. Human aortic endothelial cells were cultured in high glucose or mannitol as osmotic control for 4 days. The expression of cytokines and adhesion molecules and the adhesiveness of endothelial cells to monocytes were examined. The effects of pretreatment of GBE or N-acetylcysteine, an antioxidant, were also investigated. Either high glucose or mannitol significantly increased reactive oxygen species (ROS) production, interleukin-6 secretion, intercellular adhesion molecule-1 (ICAM-1) expression, as well as endothelial adhesiveness to monocytes. The high-glucose-induced endothelial adhesiveness was significantly reduced either by an anti-ICAM-1 antibody or by an interleukin-6 neutralizing antibody. Interleukin-6 (5 ng/ml) significantly increased endothelial ICAM-1 expression. Piceatannol, a signal transducer and activator of transcription (STAT) 1/3 inhib...Continue Reading

References

Apr 1, 1996·The Journal of Clinical Investigation·V V KunjathoorR C LeBoeuf
Dec 24, 2002·Trends in Immunology·Gilles KaplanskiCatherine Farnarier
Nov 25, 2003·Nature Cell Biology·Mark T UhlikGary L Johnson
Mar 6, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Suseela SrinivasanCatherine C Hedrick
Oct 27, 2004·Biochemical and Biophysical Research Communications·Jose M CacicedoYasuo Ido
Nov 4, 2004·American Journal of Physiology. Renal Physiology·David Sheikh-Hamad, Michael C Gustin
Oct 4, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·David R HodgeWilliam L Farrar
Nov 13, 2008·Phytotherapy Research : PTR·Lei JiYuan-yuan Gao
Feb 21, 2009·Journal of Applied Physiology·Hsiu-Chung OuWayne Huey-Herng Sheu
Mar 20, 2010·Journal of Bioenergetics and Biomembranes·Giedre BaliutyteAdolfas Toleikis
Oct 13, 2010·Cardiovascular Diabetology·Enrique Z Fisman, Alexander Tenenbaum
Jan 14, 2012·Journal of Cardiovascular Pharmacology·Giedre BaliutyteAdolfas Toleikis

❮ Previous
Next ❯

Citations

Jun 13, 2014·Phytotherapy Research : PTR·Yee-Ling Tang, Shun-Wan Chan
May 22, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Chiung-Chi PengRobert Y Peng
Nov 2, 2018·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Tao-Cheng WuJaw-Wen Chen
Jun 22, 2019·Current Vascular Pharmacology·Xiaoxue LiHui Huang
Jan 17, 2014·International Journal of Oncology·Shu-Wei Wang, Yue-Ming Sun
Jun 2, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Weidong PanTe Liu

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.