Abstract
Abdominal aortic aneurysms (AAAs) are a chronic vascular disease characterized by pathological luminal dilation. Aortic rupture is the fatal consequence of AAAs. Ginkgo biloba extracts (GBEs), a natural herb extract widely used as food supplements, drugs, and cosmetics, has been reported to suppress development of calcium chloride-induced AAAs in mice. Calcium chloride-induced AAAs do not rupture, while angiotensin II (AngII)-induced AAAs in mice have high rate of aortic rupture, implicating potentially different mechanisms from calcium chloride-induced AAAs. This study aimed to determine whether GBE would improve aortic dilation and rupture rate of AngII-induced AAAs. Male apolipoprotein E (apoE) -/- mice were infused with AngII and administered either GBE or its major active ingredients, flavonoids and ginkgolides, individually or in combination. To determine the effects of GBE in mice with established AAAs, male apoE-/- mice were firstly infused with AngII for 28 days to develop AAAs, and then administered either GBE or vehicle in mice with established AAAs, which were continuously infused with AngII for another 56 days. GBE, but not the two major active components separately or synergistically, prevented aortic rupture, but...Continue Reading
References
Sep 1, 1987·Biochemical Pharmacology·V LamantL Douste-Blazy
Jun 7, 2000·The Journal of Clinical Investigation·A DaughertyL A Cassis
Aug 5, 2000·Journal of Natural Products·P G Pietta
Mar 30, 2002·Journal of the American College of Cardiology·Georgianne Valli, Elsa Grace V Giardina
Aug 10, 2002·Journal of Vascular Surgery·M HeikkinenO Auvinen
Nov 29, 2005·Nature Medicine·Koichi YoshimuraMasunori Matsuzaki
Dec 5, 2009·Acta Pharmacologica Sinica·Qi ZhangYu Du
Jul 19, 2011·The Journal of Nutritional Biochemistry·Xiaojie XieJian-an Wang
Jul 29, 2011·Journal of Zhejiang University. Science. B·Alan DaughertyHong Lu
Oct 3, 2012·PloS One·Xiaojie XieAlan Daugherty
Dec 1, 2012·Journal of Applied Physiology·Hsiu-Chung OuShin-Da Lee
Dec 5, 2012·PloS One·Sarbani Ghoshal, Charles D Loftin
Dec 12, 2012·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Chun-Hsiung HuangYu-Hsiang Kuan
Jan 1, 2013·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·J B WildM J Bown
Jan 4, 2013·PloS One·Ou LiuHongjia Zhang
Jul 5, 2013·PloS One·Kaliappan GopalJerald M Kumar
Jul 20, 2013·Drug Metabolism Reviews·Matthias Unger
Sep 10, 2013·Journal of Ethnopharmacology·Lian WangYan Chen
Jan 7, 2014·Journal of Vascular Surgery·Ruby C LoUNKNOWN Vascular Study Group of New England,
Jan 31, 2014·Clinical Science·Sai-Wang SetoJonathan Golledge
Mar 19, 2014·Lancet·Alan KarthikesalingamMatthew M Thompson
Jan 23, 2015·Journal of the American Heart Association·Maya LandenhedJ Gustav Smith
Aug 27, 2015·Current Pharmaceutical Design·Jing LiuHong Lu
Mar 24, 2016·Langenbeck's Archives of Surgery·Thomas Schmitz-RixenR T Grundmann
Apr 20, 2017·Circulation Journal : Official Journal of the Japanese Circulation Society·Deborah A HowattHong Lu