PMID: 25727037Mar 3, 2015Paper

Ginkgolide B increases hydrogen sulfide and protects against endothelial dysfunction in diabetic rats

Croatian Medical Journal
Guo-Guang WangXue Zhao

Abstract

To evaluate the effect of ginkgolide B treatment on vascular endothelial function in diabetic rats. The study included four groups with 15 male Sprague-Dawley rats: control group; control group treated with ginkgolide B; diabetic group; and diabetic treated with ginkgolide B. The activity of superoxide dismutase (SOD), malondialdehyde content, and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase subunits, and glutathione peroxidase 1 (GPX1) protein expression were determined in aortic tissues. Vasoconstriction to phenylephrine (PHE) and vasorelaxation to acetylcholine (Ach) and sodium nitroprusside (SNP) were assessed in aortic rings. Nitric oxide (NO) and hydrogen sulfide (H2S) were measured, as well as cystathionine γ lyase (CSE) and cystathionine β synthetase (CBS) protein expression, and endothelial nitric oxide synthase (eNOS) activity. Diabetes significantly impaired PHE-induced vasoconstriction and Ach-induced vasorelaxation (P<0.001), reduced NO bioavailability and H2S production (P<0.001), SOD activity, and GPX1 protein expression (P<0.001), and increased malondialdehyde content and NADPH oxidase subunits, and CSE and CBS protein expression (P<0.001). Ginkgolide B treatment improved PHE vasoconstriction and ...Continue Reading

Citations

Feb 6, 2017·American Journal of Physiology. Cell Physiology·Nancy L KanagyAndreas Papapetropoulos
Feb 26, 2020·Phytotherapy Research : PTR·Farhad EisvandHossein Hosseinzadeh
Dec 20, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zhiyang LvYuwei Yang
Apr 4, 2021·Antioxidants·Valerio CicconeLucia Morbidelli
Jul 9, 2021·Fitoterapia·Christian J Valencia-GuzmánCésar Ibarra-Alvarado

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