Ginkgolides protect against amyloid-beta1-42-mediated synapse damage in vitro

Molecular Neurodegeneration
Clive BateAlun Williams

Abstract

The early stages of Alzheimer's disease (AD) are closely associated with the production of the Abeta1-42 peptide, loss of synapses and gradual cognitive decline. Since some epidemiological studies showed that EGb 761, an extract from the leaves of the Ginkgo biloba tree, had a beneficial effect on mild forms of AD, the effects of some of the major components of the EGb 761 extract (ginkgolides A and B, myricetin and quercetin) on synapse damage in response to Abeta1-42 were examined. The addition of Abeta1-42 to cortical or hippocampal neurons reduced the amounts of cell associated synaptophysin, a pre-synaptic membrane protein that is essential for neurotransmission, indicating synapse damage. The effects of Abeta1-42 on synapses were apparent at concentrations approximately 100 fold less than that required to kill neurons; the synaptophysin content of neuronal cultures was reduced by 50% by 50 nM Abeta1-42. Pre-treatment of cortical or hippocampal neuronal cultures with ginkgolides A or B, but not with myrecitin or quercetin, protected against Abeta1-42-induced loss of synaptophysin. This protective effect was achieved with nanomolar concentrations of ginkgolides. Previous studies indicated that the ginkgolides are platelet-a...Continue Reading

References

Jan 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H OberpichlerJ Krieglstein
Jul 26, 1988·European Journal of Pharmacology·R KorthJ Benveniste
Mar 1, 1989·Neurology·J E HamosD A Drachman
Dec 6, 1994·Proceedings of the National Academy of Sciences of the United States of America·A Lorenzo, B A Yankner
Jan 1, 1993·Journal of Cell Science. Supplement·L A Elferink, R H Scheller
Jul 23, 1996·Biochemistry·J Y LehtonenP K Kinnunen
Feb 1, 1997·Journal of Neuroscience Methods·G J Brewer
May 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·M P LambertW L Klein
Nov 21, 1998·Archives of Neurology·B S OkenJ A Kaye
Mar 16, 2001·Trends in Neurosciences·W L KleinC E Finch
Jul 5, 2001·The Journal of Biological Chemistry·S A WaschukJ A McLaurin
Jan 5, 2002·Neuroscience Letters·Tsuneo TakaderaTakao Ohyashiki
Oct 26, 2002·Science·Dennis J Selkoe
Jul 22, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Antonia H M BoutsTheo A Out
Aug 5, 2004·American Journal of Physiology. Renal Physiology·Ulla C KoppTomas Hökfelt
Sep 29, 2004·Neuron·Dominic M Walsh, Dennis J Selkoe
Oct 28, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nan SangChu Chen
May 11, 2006·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Akhlaq A Farooqui, Lloyd A Horrocks
Aug 22, 2006·Rapid Communications in Mass Spectrometry : RCM·Shujing DingA Gareth Brenton

❮ Previous
Next ❯

Citations

Aug 1, 2009·Neurotoxicity Research·Clive BateAlun Williams
May 25, 2013·Clinical Pharmacokinetics·Christian UdeMario Wurglics
Apr 9, 2010·Molecular Neurodegeneration·Clive BateAlun Williams
Nov 21, 2012·Neurobiology of Aging·Eugene O'HareRoss Jeggo
Sep 10, 2011·Acta Biochimica Et Biophysica Sinica·Antara De
Jul 24, 2014·Journal of Cellular Biochemistry·Ivana SirangeloMaria Luisa Balestrieri
Feb 18, 2010·International Journal of Molecular Sciences·Chun ShiDavid T Yew
Apr 24, 2018·The Journal of Pharmacy and Pharmacology·Priya GhumatkarSadhana Sathaye
Mar 21, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ki-Yeol Yoo, So-Young Park
Aug 14, 2018·Current Drug Targets·Duraiswamy BasavanMohan K S Kumar
Sep 6, 2019·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Guan-Jun YangChung-Hang Leung
Dec 11, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ronan LordanConstantinos A Demopoulos
Nov 22, 2012·Journal of Cellular Physiology·Ivana SirangeloMaria Luisa Balestrieri
Jun 7, 2011·Drugs & Aging·Melanie-Jayne R Howes, Elaine Perry
Feb 15, 2018·Frontiers in Aging Neuroscience·Clare RusbridgeMourad Tayebi
Apr 10, 2019·Neural Regeneration Research·Prajakta DeshpandeAmit Singh
Jul 11, 2021·Molecular Biology Reports·Martyna GachowskaJulita Kulbacka
Nov 23, 2012·ACS Chemical Neuroscience·Laramie P JamesonSergei V Dzyuba

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
enzyme-linked immunoassay

Related Feeds

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Alzheimer's Disease: Microglia

Microglia are a type of glial cell found throughout the brain and spinal cord. Microglia have been found to be associated with Alzheimer's disease development and progression. Here are the latest discoveries pertaining to Alzheimer's disease and microglia.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Astrocytes & Amyloid

Astrocytes are thought to play a role in amyloid production and have been implicated in neurodegenerative diseases such as Alzheimer’s disease. Here is the latest research on the relationship between astrocytes and amyloid.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.