Ginseng Berry Extract Rich in Phenolic Compounds Attenuates Oxidative Stress but not Cardiac Remodeling post Myocardial Infarction

International Journal of Molecular Sciences
Mihir ParikhThomas Netticadan

Abstract

The cardioprotective effects of ginseng root extracts have been reported. However, nothing is known about the myocardial actions of the phenolic compounds enriched in ginseng berry. Therefore, this study was undertaken to investigate the effects of American ginseng berry extract (GBE) in an experimental model of myocardial infarction (MI). Coronary artery ligation was performed on Sprague⁻Dawley male rats to induce MI after which animals were randomized into groups receiving either distilled water or GBE intragastrically for 8 weeks. Echocardiography and assays for malondialdehyde (MDA) and TNF-α were conducted. Flow cytometry was used to test the effects of GBE on T cell phenotypes and cytokine production. Although GBE did not improve the cardiac functional parameters, it significantly attenuated oxidative stress in post-MI rat hearts. GBE treatment also resulted in lower than control levels of TNF-α in post-MI rat hearts indicating a strong neutralizing effect of GBE on this cytokine. However, there was no effect of GBE on the proportion of different T cell subsets or ex-vivo cytokine production. Taken together, the present study demonstrates GBE reduces oxidative stress, however no effect on cardiac structure and function in...Continue Reading

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Citations

Apr 12, 2019·International Journal of Molecular Sciences·UNKNOWN International Journal of Molecular Sciences Editorial Office
Apr 1, 2020·International Journal of Molecular Sciences·Paramjit S Tappia, Heather Blewett
Jan 13, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Se Rin ChoiChoong Hwan Lee

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Methods Mentioned

BETA
coronary artery
MDA
flow cytometry

Software Mentioned

SAS
Cell Diva
Power
EchoPAC

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