Ginseng Gintonin Attenuates Lead-Induced Rat Cerebellar Impairments during Gestation and Lactation.

Biomolecules
Sung Min NamSeung-Yeol Nah

Abstract

Gintonin, a novel ginseng-derived lysophosphatidic acid receptor ligand, improves brain functions and protects neurons from oxidative stress. However, little is known about the effects of gintonin against Pb-induced brain maldevelopment. We investigated the protective effects of gintonin on the developing cerebellum after prenatal and postnatal Pb exposure. Pregnant female rats were randomly divided into three groups: control, Pb (0.3% Pb acetate in drinking water), and Pb plus gintonin (100 mg/kg, p.o.). Blood Pb was increased in dams and pups; gintonin treatment significantly decreased blood Pb. On postnatal day 21, the number of degenerating Purkinje cells was remarkably increased while the number of calbindin-, GAD67-, NMDAR1-, LPAR1-immunoreactive intact Purkinje cells, and GABA transporter 1-immunoreactive pinceau structures were significantly reduced in Pb-exposed offspring. Following Pb exposure, gintonin ameliorated cerebellar degenerative effects, restored increased pro-apoptotic Bax, and decreased anti-apoptotic Bcl2. Gintonin treatment attenuated Pb-induced accumulation of oxidative stress (Nrf2 and Mn-SOD) and inflammation (IL-1β and TNFα,), restoring the decreased cerebellar BDNF and Sirt1. Gintonin ameliorated Pb...Continue Reading

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Citations

Dec 23, 2020·Neurotoxicology·Vanessa NaffaaAnne-Laure Schang
Jan 21, 2021·Biomolecules·Barbara RomanoRaffaele Capasso
May 25, 2021·Archives of Toxicology·Alexey A TinkovMichael Aschner
Aug 14, 2021·Frontiers in Neuroscience·Dongqiong XiaoYi Qu

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Datasets Mentioned

BETA
GAD67

Methods Mentioned

BETA
Assay
protein assay

Software Mentioned

NIH ImageJ

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