Ginsenoside C-Mx Isolated from Notoginseng Stem-leaf Ginsenosides Attenuates Ultraviolet B-mediated Photoaging in Human Dermal Fibroblasts

Photochemistry and Photobiology
Xiao-Yi LiuTae Hoo Yi

Abstract

Notoginseng is a traditional herbal medicine widely used for medicinal therapy in Asia, as it contains numerous ginsenosides with pharmacological effects. In this study, we submitted Notoginseng stem-leaf (NGL) ginsenosides to an enzyme to create a reaction with the monomer products of ginsenoside C-Mx and then investigated the ability of ginsenoside C-Mx to protect the skin against ultraviolet B-induced injury in normal human dermal fibroblasts (NHDFs). Ginsenoside C-Mx alleviated UVB-induced intracellular reactive oxygen species (ROS), MMP-1 and IL-6 expression while accelerating TGF-β and procollagen type I secretion. In addition, ginsenoside C-Mx reversed UVB-induced procollagen type I reduction by regulating the TGF-β/Smad signaling pathway. Moreover, ginsenoside C-Mx inhibited activation of AP-1 transcription factor, an inducer of MMPs. Ginsenoside C-Mx displayed an outstanding antioxidant capacity, increasing expression of cytoprotective antioxidants such as HO-1 and NQO-1 expression by enhancing the nuclear accumulation of Nrf2. Interestingly, application of ginsenoside C-Mx treatment (1, 10, 20 μm) significantly diminished UVB-induced suppressed NF-κB expression, decreasing the over-released inflammatory cytokines. Tak...Continue Reading

References

Jul 11, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R B WeissB Leyland-Jones
Nov 26, 1999·Biochemical Pharmacology·A S AtteleC S Yuan
Aug 23, 2002·The Journal of Investigative Dermatology·TaiHao QuanGary J Fisher
Sep 16, 2003·Chemical Research in Toxicology·Jacintha M ShentonJack P Uetrecht
Nov 5, 2003·Gene·Shen-Hsi YangAlan J Whitmarsh
Dec 8, 2004·The Journal of Biological Chemistry·Taihao QuanGary J Fisher
Mar 8, 2005·Mutation Research·Farrukh AfaqHasan Mukhtar
Jul 29, 2006·The Journal of Pharmacy and Pharmacology·T B Ng
Jan 4, 2007·The Journal of Pathology·L Baumann
Feb 3, 2009·The Journal of Biological Chemistry·Truyen NguyenCecil B Pickett
Jun 12, 2010·Chinese Medicine·Kar Wah Leung, Alice Sze-Tsai Wong
Jan 15, 2014·Photodermatology, Photoimmunology & Photomedicine·Michelle R IannaconeAdèle C Green
Jul 6, 2014·Skin Pharmacology and Physiology·Ute WölfleChristoph M Schempp
Jul 25, 2014·Biological & Pharmaceutical Bulletin·Chang-Jin LimHyun-Joo Jung
Aug 15, 2014·Journal of Agricultural and Food Chemistry·Jing-Rong WangZhi-Hong Jiang
Jan 21, 2015·Matrix Biology : Journal of the International Society for Matrix Biology·Steven R Van Doren
Aug 20, 2015·Bioscience, Biotechnology, and Biochemistry·Sun-Joo OhChang-Jin Lim
Jul 13, 2017·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Cesare Mancuso, Rosaria Santangelo
May 3, 2018·Journal of Ginseng Research·Eunji KimJunseong Park

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.