Ginsenoside Drug Nanocomposites Prepared by the Aerosol Solvent Extraction System for Enhancing Drug Solubility and Stability

Pharmaceutics
Cheng TaoYuan Le

Abstract

Ginsenosides are the pharmacologically active constituents of ginseng. So far, more than 30 ginsenosides have been identified and widely used in pharmaceutical formulations. However, the therapeutic applications of ginsenosides are hampered by their poor solubility and low bioavailability. In this study, we selected two of the most important ginsenosides-Re and Rh₂ as model drugs to prepare ginsenoside drug nanocomposites (NanoGS) using the simple aerosol solvent extraction system (ASES) technique to address the poor solubility and bioavailability of these compounds. Compared with raw ginsenosides, NanoGS exhibited significantly enhanced dissolution rate owing to their low crystallinity and high surface area. Furthermore, in vitro cellular investigations showed that NanoGS-Rh₂ exhibited outstanding anticancer activity against MCF-7 cancer cells. Therefore, this study is expected to provide a promising strategy that could optimize and broaden the applications of ginsenosides, as well as other water-insoluble drugs in pharmaceutical formulations.

References

Aug 18, 2001·Planta medica·M RudakewichC G Benishin
Aug 15, 2002·International Journal of Pharmaceutics·Marazban SarkariKeith P Johnston
Oct 31, 2002·Angewandte Chemie·Dieter Horn, Jens Rieger
Feb 21, 2003·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Elaine Merisko-LiversidgeEugene R Cooper
Jul 25, 2003·European Journal of Pharmacology·Xiao-Chun ChenChao-Hui Zhao
Mar 17, 2004·International Journal of Pharmaceutics·S Sethia, E Squillante
Mar 20, 2004·Journal of Pharmaceutical and Biomedical Analysis·N Buchi NaiduG Becket
Jun 14, 2005·Biochimica Et Biophysica Acta·Jing-Tian XieChun-Su Yuan
Feb 25, 2006·European Journal of Pharmacology·Jing-Tian XieChun-Su Yuan
Jun 15, 2007·International Journal of Pharmaceutics·Xiang-Shan LiJimmy Yun
Jul 10, 2007·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·S StegemannH Lindén
Aug 19, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Lennart LindforsUlf Olsson
Oct 27, 2007·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jun LeiYi-nan Zheng
Dec 11, 2007·Canadian Journal of Physiology and Pharmacology·David D KittsChun Hu
May 9, 2008·Journal of Asian Natural Products Research·Li-Min ChenWen-Xiang Hu
Jun 7, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Elena V Batrakova, Alexander V Kabanov
Jun 2, 2009·International Journal of Pharmaceutics·Hany S M AliNicholas Blagden
Dec 26, 2009·International Immunopharmacology·Xiaoming SongSonghua Hu
Jun 12, 2010·Chinese Medicine·Kar Wah Leung, Alice Sze-Tsai Wong
Sep 3, 2011·Cardiovascular Therapeutics·Lu PengJing-Tian Xie
Oct 16, 2012·Journal of Pharmacy & Bioallied Sciences·Yomesh PatelKrutika Sawant
Nov 6, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Hongbo WangFeng-Hua Fu
Feb 5, 2014·Journal of Nanobiotechnology·Li ShangGerd Ulrich Nienhaus
Jul 22, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Elisabeth LenzPeter Kleinebudde
Jul 9, 2017·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Piotr Cysewski, Maciej Przybyłek
Jun 5, 2018·Pharmaceutics·Okky Dwichandra PutraHidehiro Uekusa

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Methods Mentioned

BETA
scanning electron microscopy
X-ray
flow cytometry
dynamic light scattering

Software Mentioned

GraphPad
Instat
SPSS

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