Ginsenoside improves papillary thyroid cancer cell malignancies partially through upregulating connexin 31

The Kaohsiung Journal of Medical Sciences
Li XuYuan-Bo Sun

Abstract

Connexin 31 (Cx31) is considered a suppressor for many tumors. Ginsenoside (Rg1) is a traditional Chinese herb that is widely acknowledged due to its anti-tumor characteristics. However, limited studies have focused on the role of Rg1 in papillary thyroid cancer (PTC) cells. In the current study, we found that the expression of Cx31 in thyroid cancer tissues and thyroid cancer cell lines was significantly lower than that in normal thyroid epithelial tissues and cell lines. Overexpression of Cx31 reduced thyroid cancer cell proliferation, migration and invasion. Furthermore, we found that Rg1 significantly enhanced the expression of Cx31. Moreover, the proliferation and migration of IHH-4 and BCPAP cells were significantly reduced by Rg1 treatment. In contrast, the silencing of Cx31 enhanced the expression of Ki67 and proliferating cell nuclear antigen (PCNA). Meanwhile, treatment with Rg1 significantly decreased the protein levels of Ki67 and PCNA, but these effects could be abolished by transfection with si-Cx31. In summary, we provide novel evidence that the expression of Cx31 was decreased in thyroid cancer cells, but Rg1 treatment could significantly enhance the expression of Cx31 thereby suppressing thyroid cancer cell pro...Continue Reading

References

Feb 5, 2003·Biology of the Cell·Marc Mesnil
Oct 27, 2007·Developmental Biology·Qingyi Zheng-FischhöferKlaus Willecke
Nov 29, 2007·American Journal of Physiology. Endocrinology and Metabolism·Gaëlle ProstBernard Rousset
Feb 25, 2010·Annals of Surgical Oncology·Stephen B Edge, Carolyn C Compton
Oct 3, 2015·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Faisal AzizQiu Yan
Feb 18, 2016·Cancer Letters·Christina L GrekElizabeth S Yeh
May 26, 2016·Asian Pacific Journal of Cancer Prevention : APJCP·Jun QianLi-Yu Qian
May 28, 2016·BMC Cell Biology·Jean X Jiang, Silvia Penuela
Aug 18, 2016·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Ruowen ZhangSeema Somji
Oct 27, 2016·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·P G CalòC P Lombardi
Dec 3, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xia ZhengXu Li
Feb 23, 2017·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Simona CatalaniSerena Benedetti
Mar 8, 2017·World Journal of Surgery·Sapana BothraSabaretnam Mayilvaganan
Mar 16, 2017·Thyroid : Official Journal of the American Thyroid Association·Nicole A CiprianiPeter M Sadow

❮ Previous
Next ❯

Citations

Mar 7, 2019·American Journal of Therapeutics·Valentin ChioncelCrina Sinescu
Oct 31, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Xiaowei ZhouGuohui Li
Sep 29, 2019·World Journal of Gastroenterology : WJG·Huan LiXiao-Ming Liu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.