Ginsenoside Rd reverses cognitive deficits by modulating BDNF-dependent CREB pathway in chronic restraint stress mice

Life Sciences
Haixia WangXinmin Liu

Abstract

Cognitive impairment has been widely recognized as a common symptom of chronic stress. Ginsenoside Rd (GRd), the major active compound in Panax ginseng, was previously reported in various neurological researches. However, little research is available regarding on the effect of GRd on cognitive improvement in mice subjected to chronic stress. In the present study, we investigated the neuroprotective effects of GRd in chronic restraint stress (CRS)-induced cognitive deficits and explored the potential mechanism in male C57BL/6J mice. Our results demonstrated that oral administration of GRd for 28 days markedly increased the spontaneous alternation in Y-maze and the relative discrimination index in novel object or location recognition tests following CRS. Additionally, GRd treatment considerably increased the antioxidant enzymes activities in the hippocampus. The expression levels of hippocampus and serum inflammation factors in the CRS groups were also counter-regulated by GRd treatment. Meanwhile, GRd treatment could reverse CRS-induced the decrease in phosphorylated phosphoinositide 3-kinase (PI3K), camp-reflecting element binding protein (CREB), brain-derived neurotrophic factor (BDNF) and tyrosine kinase B (TrkB) expression i...Continue Reading

References

Jan 1, 1981·Neuroscience and Biobehavioral Reviews·R J KatzB J Carroll
Dec 9, 1997·Neuron·S FinkbeinerM E Greenberg
Mar 17, 2001·Nature Reviews. Neuroscience·H Eichenbaum
Jun 19, 2004·The International Journal of Neuroscience·Ismail AbidinEmel Sahin
Oct 19, 2004·Clinical Microbiology Reviews·R Bryan RockPhillip K Peterson
Mar 2, 2005·Nature Reviews. Immunology·Ronald Glaser, Janice K Kiecolt-Glaser
Mar 11, 2005·Neurochemical Research·Fernanda U FontellaCarla Dalmaz
Oct 2, 2007·Behavioural Brain Research·Ryan L Wright, Cheryl D Conrad
Jan 20, 2009·Biological Psychiatry·Andrew H MillerCharles L Raison
May 26, 2009·Neuroscience and Biobehavioral Reviews·Tatyana Buynitsky, David I Mostofsky
Aug 7, 2012·Archives of Pharmacal Research·Xiao-Lai YangYong-Jie Wu
Mar 29, 2013·Biochemical and Biophysical Research Communications·Dong-Ho KwonYea-Hyun Leem
Jun 7, 2014·Pharmacological Reports : PR·Dominik Wincewicz, Jan J Braszko
Dec 5, 2014·Stress : the International Journal on the Biology of Stress·Mingchao LiuJingyuan Chen
Feb 11, 2015·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Naijing LiPing He
Sep 12, 2015·Journal of Molecular Neuroscience : MN·Juanfang LiuGang Zhao
Oct 8, 2015·Trends in Neurosciences·Raz YirmiyaRonen Reshef
Jan 7, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Saeed SamarghandianFariborz Samini
Mar 25, 2017·The International Journal of Neuropsychopharmacology·Naimesh SolankiSamina Salim
Jun 29, 2017·Molecular Medicine Reports·Qian ZhangXiaoyang Chen
May 31, 2018·Nutritional Neuroscience·Caitlin O B YollandSusan L Rossell
Oct 12, 2018·Nature Reviews. Molecular Cell Biology·Lorenzo GalluzziGuido Kroemer
Dec 12, 2018·Methods in Molecular Biology·Ann-Katrin KraeuterZoltán Sarnyai
Nov 16, 2019·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Noha H SayedAhmed S Kamel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved