Ginsenoside Re Promotes Nerve Regeneration by Facilitating the Proliferation, Differentiation and Migration of Schwann Cells via the ERK- and JNK-Dependent Pathway in Rat Model of Sciatic Nerve Crush Injury

Cellular and Molecular Neurobiology
Lei WangQian Tan

Abstract

Exploring effective drugs that are capable of promoting nerve regeneration has gained much attention. Ginsenoside Re (Re) is the main ingredient of ginseng berries and roots. Research in the area has shown that ginsenoside Re exhibits multiple pharmacological activities via different mechanisms both in vivo and in vitro. But the potential therapeutic effects of Re on sciatic nerve crush injury (SNC) have been little investigated. Herein, we investigated the protect effect of Re on peripheral nerve regeneration in a rat SNC model. Walking track analysis revealed that Re treatment significantly promoted functional recovery of crushed sciatic nerve in rats. The expression of PCNA in rat sciatic nerve was up-regulated by Re treatment, and peaked when the concentration of Re was 2.0 mg/kg. Using immunofluorescent staining, we found that Re greatly increased the expression of GAP-43 and S100 in injured rat sciatic nerve. Furthermore, we evaluated the effects of Re on proliferation, differentiation, and migration of Schwann cells in SNC rat models. Our studies reveal that Re promotes nerve regeneration is depend on ERK1/2 and JNK1/2 signaling pathway. Elevated Oct-6 expression and featured morphological changes indicated that Re facil...Continue Reading

References

Jan 1, 1990·Annual Review of Neuroscience·J W Fawcett, R J Keynes
Mar 24, 1989·Biochimica Et Biophysica Acta·C M TengT F Huang
May 1, 1995·Journal of Neuroscience Methods·L de Medinaceli
Nov 26, 1999·Biochemical Pharmacology·A S AtteleC S Yuan
Jun 9, 2000·Annual Review of Neuroscience·J L Goldberg, B A Barres
Feb 13, 2003·Neuroscience Letters·Katerina AkassoglouSidney Strickland
Jul 9, 2004·The EMBO Journal·Marie C HarrisinghAlison C Lloyd
Jul 30, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Toru OgataSakae Tanaka
Jun 14, 2005·Biochimica Et Biophysica Acta·Jing-Tian XieChun-Su Yuan
Sep 2, 2005·Nature Reviews. Neuroscience·Kristjan R Jessen, Rhona Mirsky
Jun 22, 2006·Journal of the Peripheral Nervous System : JPNS·Xander SmitJohan W van Neck
Sep 12, 2006·Current Opinion in Neurobiology·Klaus-Armin Nave, James L Salzer
Oct 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Céline CharvetAmnon Altman
Jul 31, 2007·Pharmacology & Therapeutics·Michael SchumacherAlejandro F De Nicola
Mar 8, 2008·FEBS Letters·E A Papakonstanti, C Stournaras
Apr 4, 2008·Advances and Technical Standards in Neurosurgery·G BlaauwJ W Vredeveld
Apr 4, 2008·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Li ChenAiguo Shen
May 17, 2008·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·William W Campbell
Jan 1, 1989·The Western Journal of Medicine·V R Hentz
Nov 26, 2009·The American Journal of Chinese Medicine·Kun Shan HuangHsiu-Chung Ou
Apr 21, 2010·Nature Reviews. Neurology·Carla TaveggiaLawrence Wrabetz
Dec 24, 2011·Trends in Neurosciences·Jorge A PereiraUeli Suter
Dec 27, 2011·Pharmacology, Biochemistry, and Behavior·Yao-Wu LiuXiao-Xing Yin
Feb 9, 2012·Chinese Medicine·Dacheng PengJingtian Xie
Sep 28, 2012·Journal of Molecular Histology·Xiaolong DengYouhua Wang
Oct 19, 2012·Journal of Molecular Histology·Youhua WangGuangfei Xu
Oct 31, 2012·Journal of Molecular Neuroscience : MN·Hao WuYouhua Wang
Jul 31, 2013·Current Opinion in Neurobiology·Thomas D Glenn, William S Talbot
Apr 22, 2014·Journal of Ginseng Research·Sena LeeYoun-Jung Kim
Jun 26, 2014·Cellular and Molecular Neurobiology·Zhengming ZhouHuiguang Yang

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Citations

Dec 10, 2015·Neurochemical Research·Heitor G Araújo-FilhoJullyana S S Quintans
Jun 18, 2019·Drug Metabolism Reviews·Olimpiu Bota, Lucian Fodor
May 11, 2018·Journal of Korean Neurosurgical Society·Tae-Young JungHee-Jo Baek
Jun 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Edward J Calabrese
Nov 10, 2017·Neurochemical Research·Dongdong GuoXingjing Luo
May 2, 2017·BioMed Research International·Xian-Hu ZhouShi-Qing Feng
Jun 6, 2021·BMC Complementary Medicine and Therapies·Young Jun KimSeung-Yeon Cho

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