Ginsenoside Rg1 ameliorates liver fibrosis via suppressing epithelial to mesenchymal transition and reactive oxygen species production in vitro and in vivo

BioFactors
Xiaoyu WeiWenxiang Huang

Abstract

Liver fibrosis remains a major cause of morbidity and mortality with a complicated etiology and notorious complications, but there is a lack of efficacious therapeutics. Epithelial to mesenchymal transition (EMT) has a central role in the course of liver fibrosis, and thus, prevention of the development of EMT may control and even reverse liver fibrosis. This study aimed to examine the beneficial effect of ginsenoside Rg1, a phrenological active component isolated from Ginseng, and interrogate the mechanism in vitro and in vivo, with a focus on transforming growth factor-β (TGF-β)/Smad and Nrf2-mediated signaling pathways. We employed a TGF-β-induced EMT model in HSC-T6 cells and CCl4 -induced liver fibrosis in animal. We found that ginsenoside Rg1 significantly reduced cell proliferation and reversed transforming growth factor-β (TGF-β)-induced EMT in HSC-T6 cells; and ginsenoside Rg1 induced cell apoptosis, Ginsenoside Rg1 decreased the cellular level of collagen I and III in HSC-T6 cells, indicating the amelioration of fibrosis. We showed that ginsenoside Rg1 reduced cellular reactive oxygen species (ROS). We also observed similar beneficial effects of ginsenoside Rg1 in vivo. The data showed that ginsenoside Rg1 decreased t...Continue Reading

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Citations

Feb 6, 2020·Clinical and Experimental Pharmacology & Physiology·Xiao ChenZhigang Guo
Oct 13, 2018·Journal of Complementary & Integrative Medicine·Hajar F KaraaliJamilah M Borjac
Feb 23, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Yimin ShiYimeng Li
Jun 25, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zhe MaZhidong Liu
Jan 8, 2021·Frontiers in Cell and Developmental Biology·Jacopo Di GregorioVincenzo Flati
Mar 6, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Chan MoZhiping Lv

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