Ginsenoside Rg1 Ameliorates Rat Myocardial Ischemia-Reperfusion Injury by Modulating Energy Metabolism Pathways

Frontiers in Physiology
Lin LiJing-Yan Han

Abstract

As a major ingredient of Radix ginseng, ginsenoside Rg1 (Rg1) has been increasingly recognized to benefit the heart condition, however, the rationale behind the role is not fully understood. In vitro study in H9c2 cardiomyocytes has shown the potential of Rg1 to increase ATP content in the cells. We thus speculated that the protective effect of Rg1 on heart ischemia and reperfusion (I/R) injury implicates energy metabolism regulation. The present study was designed to verify this speculation. Male Sprague-Dawley rats were subjected to 30 min of occlusion of left coronary anterior descending artery followed by reperfusion for 90 min. Rg1 (5 mg/kg/h) was continuously administrated intravenously 30 min before occlusion until the end of reperfusion. Myocradial blood flow and heart function were monitored over the period of I/R. Myocardial infarct size, structure and apoptosis, energy metabolism, and change in RhoA signaling pathway were evaluated 90 min after reperfusion. Binding of Rg1 to RhoA was assessed using Surface Plasmon Resonance (SPR). Rg1 prevented I/R-elicited insults in myocardium, including myocardial infarction and apoptosis, decreased myocardial blood flow (MBF) and heart function, and alteration in myocardium struc...Continue Reading

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Citations

Jun 26, 2018·Canadian Journal of Physiology and Pharmacology·Xiaohong Tracey Gan, Morris Karmazyn
Feb 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Eun Ju ShinYoungkyung Rhee
Jun 18, 2020·Journal of Cellular and Molecular Medicine·Haitao YuQian Tong
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Wenjing LiaoHe Sun
Jun 29, 2021·Frontiers in Physiology·Jing-Yan HanQiao-Bing Huang
Jun 21, 2020·Mini Reviews in Medicinal Chemistry·Jiazhen WangQingguo Meng
Aug 19, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Wei ZhangYawei Xu

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Methods Mentioned

BETA
ELISA
Surface Plasmon Resonance
chip
electron microscopy

Software Mentioned

Image
Biacore T200
Pro Plus
LDPIwin

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