Ginsenoside Rg1 attenuates protein aggregation and inflammatory response following cerebral ischemia and reperfusion injury

European Journal of Pharmacology
Tianyang ZhengYong Chen

Abstract

Ginsenoside Rg1 (GS Rg1) is a glycosylated triterpenoid saponin extracted from Panax ginseng. We aim to investigate the impact of GS Rg1 on protein aggregation and inflammatory response in a cerebral ischemia/reperfusion (I/R) injury model. Rats were administered different doses of GS Rg1 (10, 20, or 40 mg/kg/day) or nimodipine (1 mg/kg/day) for 5 consecutive days. Cerebral I/R injury was induced by middle cerebral artery occlusion for 2 h followed by a 22 h reperfusion period. Next, we examined the differences in infarct volume and neurological deficit via TTC staining and Longa's scoring, respectively. Furthermore, the differences in protein aggregates, proteasome, IκBα and NF-κB in the cerebral cortices were investigated through western blotting. The distribution of ubiquitin, proteasome and NF-κB in the neocortex were examined through immunohistochemistry. Pro-inflammatory cytokines were measured using ELISA and proteasome activity was determined by fluorometric peptidaseassay. Treatment with GS Rg1 40 mg/kg resulted in a significantly lower infarct volume and improved the neurological deficit score as well as the histological appearance compared to the control I/R group (P < 0.05). GS Rg1 treatment resulted in significantl...Continue Reading

References

Jan 1, 1989·Stroke; a Journal of Cerebral Circulation·E Z LongaR Cummins
Dec 1, 1989·Stroke; a Journal of Cerebral Circulation·M D Ginsberg, R Busto
Aug 20, 1993·Brain Research·T HayashiM Matsuda
Jan 8, 1999·Stroke; a Journal of Cerebral Circulation·A M KaufmannH Yonas
Dec 10, 2000·The Journal of Biological Chemistry·H WellmannC Kaltschmidt
Dec 5, 2002·Cell·Vishva Dixit, Tak W Mak
Dec 25, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Anthony J WilliamsFrank C Tortella
Aug 28, 2003·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Massimo Stefani, Christopher M Dobson
Jul 24, 2004·Nature Medicine·Christopher A Ross, Michelle A Poirier
Sep 24, 2004·Cancer Cell·Bharat B Aggarwal
May 14, 2005·Antioxidants & Redox Signaling·Erin H Norris, Benoit I Giasson
Dec 13, 2005·Revue neurologique·Y SamsonH Hosseini
Feb 24, 2006·Neuroscience Letters·Nils HenningerNancy E Stagliano
Nov 3, 2007·Stroke; a Journal of Cerebral Circulation·Pengfei GeBingren Hu
Feb 13, 2008·Cell·Matthew S Hayden, Sankar Ghosh
Feb 13, 2009·Stroke; a Journal of Cerebral Circulation·Rodica E PetreaPhilip A Wolf
Mar 2, 2010·Nature Reviews. Drug Discovery·Adriano Aguzzi, Tracy O'Connor
Oct 1, 2010·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Midori A YenariRaymond A Swanson
Oct 30, 2010·Current Opinion in Cell Biology·Guillermo MariñoGuido Kroemer
Jun 16, 2012·Stroke; a Journal of Cerebral Circulation·Karin HochrainerCostantino Iadecola
Jan 15, 2013·Current Opinion in Immunology·Jueqi Chen, Zhijian J Chen
Mar 14, 2013·QJM : Monthly Journal of the Association of Physicians·J S BalamiA M Buchan
Oct 26, 2013·Progress in Neurobiology·Margarida V CaldeiraCarlos B Duarte
Jul 8, 2015·Journal of Thrombosis and Haemostasis : JTH·G J Jacquin, B A van Adel
Nov 6, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Nan LiuYonghua Huang
Nov 29, 2016·Expert Review of Proteomics·Paulo BastosRui Vitorino
Oct 11, 2017·Emergency Medicine Clinics of North America·Courtney R Cassella, Andy Jagoda
May 10, 2018·Frontiers in Neurology·Xiao-Yi XiongQing-Wu Yang
Jun 18, 2018·Naunyn-Schmiedeberg's Archives of Pharmacology·Maha Mohammed Abdel-FattahAhmed Mohamed Mansour

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Citations

Jan 16, 2020·Current Pharmaceutical Design·Joana BickerAmílcar Falcão
Feb 25, 2020·Oxidative Medicine and Cellular Longevity·Chunli ChenLiuwang Zeng
May 11, 2021·Frontiers in Pharmacology·Qian XieDaoyin Gong
May 20, 2021·Oxidative Medicine and Cellular Longevity·Hui XuMingfu Wang
Nov 1, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Hanbing LiuXiaohui Fan

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