Abstract
This study tested the effect of ginsenoside Rg1 (G-Rg1) in cyclosporin A (CsA)-induced endoplasmic reticulum (ER) stress on renal tubular cell apoptosis in a rat model of chronic CsA nephropathy. Twenty-two Sprague-Dawley rats were randomized into 3 groups: a control group, a model group (CsA 25 mg/kg per day), and a G-Rg1 treatment group (CsA 25 mg/kg per day and G-Rg1 20 mg/kg per day). We examined the effects of G-Rg1 on histopathology, terminal deoxynucleotidyl transferase dUTP nick-end labeling staining, and expression of glucose-regulated protein 78, CCAAT/enhancer-binding protein homologous protein, and caspase-3 by using Western blot analysis. G-Rg1 attenuated CsA-induced tubulointerstitial fibrosis and reduced tubular epithelial cell apoptosis as assessed by terminal deoxynucleotidyl transferase dUTP nick-end labeling staining and caspase-3 expression. Compared with the model group, it reduced the expression of glucose-regulated protein 78 and CCAAT/enhancer-binding protein homologous protein (0.12 ± 0.03 vs 0.48 ± 0.05 [P < .01]; 0.55 ± 0.11 vs 1.08 ± 0.07 [P < .05]), respectively. G-Rg1 mitigates the progression of chronic CsA nephropathy, at least in part, through inhibition of ER stress-triggered tubular cell apopt...Continue Reading
References
Apr 29, 1998·Kidney International·S E ThomasR J Johnson
Apr 25, 2008·American Journal of Nephrology·Sang Woo HanChul Woo Yang
Sep 13, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·N PalletD Anglicheau
Nov 7, 2008·Journal of Zhejiang University. Science. B·Xi-Sheng XieJun-Ming Fan
Dec 23, 2008·Journal of Ethnopharmacology·Xi-Sheng XieJun-Ming Fan
Oct 30, 2010·Phytotherapy Research : PTR·Xi-Sheng XieJun-Ming Fan
Mar 23, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Kuen-Daw TsaiWei Chen
Jun 23, 2011·Transplantation Proceedings·Y TaoZ Luo
Sep 24, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Mallikarjuna KoriviChia-Hua Kuo
May 23, 2012·Journal of the International Society of Sports Nutrition·Szu-Hsien YuChia-Hua Kuo
Jan 9, 2013·American Journal of Nephrology·Zheng XiaoYouping Li
Jun 7, 2013·European Journal of Medical Research·Chang-yi LiDao-xin Wang
Jul 13, 2013·International Journal of Biological Sciences·Junxiong MaLiangbi Xiang
Feb 25, 2014·Journal of Translational Medicine·Yu Ah HongSungjin Chung
Mar 19, 2014·Acta Pharmacologica Sinica·Nan MaoJun-ming Fan
Citations
Feb 13, 2016·Journal of Cellular and Molecular Medicine·Haitao YuQuan Liu
Mar 16, 2016·Pharmacology Research & Perspectives·Fabienne Foufelle, Bernard Fromenty
Feb 20, 2016·The Journal of Pharmacology and Experimental Therapeutics·Yan WangShali Wang
Jun 15, 2016·BioMed Research International·Agnieszka KorolczukJoanna Irla-Miduch
Nov 1, 2016·International Urology and Nephrology·Qi-Feng LiuSha-Sha Li
Mar 29, 2019·Mediators of Inflammation·Qian-Lu WangXian-Zhong Xiao
Apr 3, 2018·Biological & Pharmaceutical Bulletin·Sha-Sha LiQi-Feng Liu
Jun 1, 2021·BioMed Research International·Yu LiuShu-Ju Li
Aug 7, 2021·Advanced Drug Delivery Reviews·Huan XuLeaf Huang