Ginsenoside Rg3 antagonizes adriamycin-induced cardiotoxicity by improving endothelial dysfunction from oxidative stress via upregulating the Nrf2-ARE pathway through the activation of akt

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Xiaoying WangXiumei Gao

Abstract

Adriamycin (ADM) is an antineoplastic agent that is effective against a wide range of cancers, but cardiac toxicity limits its clinical application. Ginsenoside Rg3 (Rg3), an anti-cancer active ingredient of Panax ginseng, was reported to have anti-oxidative, anti-apoptotic, and cardioprotective properties. The current study aimed to investigate the possible protective effect of Rg3 against ADM-induced cardiotoxicity. The activity of Rg3 to improve endothelial dysfunction was processed both in vivo and in vitro. We investigated the cardioprotective effect of Rg3 on ADM treated rats by echocardiography. The endothelial dysfunction was assessed using an aortic ring assay. Cardiac microvascular endothelial cells were cultured to investigate the effects of Rg3 on ADM-treated cells. Results showed that Rg3 could ameliorate the decrease in the ejection fraction and fractional shortening that was induced by ADM, and improve the left ventricular outflow. The aortic ring assay showed that Rg3 could partially recover the abnormal vascular function. In vitro studies showed that Rg3 could promote cell viability to attenuate ADM induced oxidative damage and apoptosis. This counteraction was achieved partially via activation of the Nrf2-ARE ...Continue Reading

References

Nov 1, 1979·Annals of Internal Medicine·D D Von HoffF M Muggia
Jun 25, 1998·The Journal of Cell Biology·S TanD Schubert
Sep 24, 1998·The New England Journal of Medicine·P K Singal, N Iliskovic
Dec 31, 2002·Journal of Molecular and Cellular Cardiology·Semon WuYing-Shiung Lee
Apr 4, 2008·Investigative Ophthalmology & Visual Science·Ling WangJiyang Cai
Oct 30, 2009·Archivum Immunologiae Et Therapiae Experimentalis·Yi-Wei ZhangLei Wei
Feb 5, 2010·Chinese Journal of Integrative Medicine·Xiao-ying WangBo-li Zhang
Jan 22, 2011·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Keiko TaguchiMasayuki Yamamoto
Mar 3, 2011·Archives of Toxicology·Liam Baird, Albena T Dinkova-Kostova
Feb 11, 2014·European Journal of Pharmacology·Eman M MantawyEbtehal El-Demerdash

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Citations

Jun 7, 2017·Medicinal Research Reviews·Hong-Yi QiHui Ma
Jun 6, 2017·Drug Development and Industrial Pharmacy·Shaozhi ZhangQiu Yan
Jan 29, 2019·The American Journal of Hospice & Palliative Care·Mellar P Davis, Bertrand Behm
May 16, 2017·Oxidative Medicine and Cellular Longevity·Ying LiangYouchu Ma
Jan 19, 2017·International Journal of Molecular Medicine·Mengyao SunHong Zhang
Oct 19, 2017·The Journal of Endocrinology·Jin-Bong LeeYoung-Jun Park
Sep 29, 2020·Phytotherapy Research : PTR·Fatemeh YarmohammadiGholamreza Karimi
Jul 25, 2019·Chinese Medicine·Zhengrong ZhangGuoqi Zhu
Dec 29, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yao LiuDaidi Fan
Oct 21, 2019·Fitoterapia·Giuseppe CarotaSebastiano Intagliata
Jul 12, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Cun LiuChanggang Sun

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