Ginsenoside Rg3 sensitizes human non-small cell lung cancer cells to γ-radiation by targeting the nuclear factor-κB pathway

Molecular Medicine Reports
Lei WangGuo-Jun Zhang

Abstract

At present, it is elusive how non-small cell lung cancer (NSCLC) develops resistance to γ-radiation; however, the transcription factor nuclear factor-κB (NF-κB) and NF-κB-regulated gene products have been proposed as mediators. Ginsenoside Rg3 is a steroidal saponin, which was isolated from Panax ginseng. Ginsenoside Rg3 possesses high pharmacological activity and has previously been shown to suppress NF-κB activation in various types of tumor cell. Therefore, the present study aimed to determine whether Rg3 could suppress NF-κB activation in NSCLC cells and sensitize NSCLC to γ-radiation, using an NSCLC cell line and NSCLC xenograft. A clone formation assay and lung tumor xenograft experiment were used to assess the radiosensitizing effects of ginsenoside Rg3. NF-κB/inhibitor of NF-κB (IκB) modulation was ascertained using an electrophoretic mobility shift assay and western blot analysis. NF-κB-regulated gene products were monitored by western blot analysis. The present study demonstrated that ginsenoside Rg3 was able to sensitize A549 and H1299 lung carcinoma cells to γ-radiation and significantly enhance the efficacy of radiation therapy in C57BL/6 mice bearing a Lewis lung carcinoma cell xenograft tumor. Furthermore, ginsen...Continue Reading

References

Oct 28, 1998·Proceedings of the National Academy of Sciences of the United States of America·N Li, M Karin
Jan 5, 2001·Journal of Natural Products·W Y KimJ H Park
Feb 27, 2004·Oncogene·Damodaran ChendilMansoor M Ahmed
Apr 3, 2004·Nucleic Acids Research·Wesley D BlockSusan P Lees-Miller
Apr 6, 2006·Nature Clinical Practice. Oncology·Wilfried EberhardtMartin Stuschke
Feb 24, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Carter Van Waes
May 5, 2007·Clinical Oncology : a Journal of the Royal College of Radiologists·P Wardman
Apr 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ajaikumar B KunnumakkaraSunil Krishnan
May 6, 2008·Apoptosis : an International Journal on Programmed Cell Death·Geoffrey E JohnsonTom K Hei
Feb 13, 2009·Apoptosis : an International Journal on Programmed Cell Death·Han-Ming Shen, Vinay Tergaonkar
Sep 29, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Rohit LalHartmut Kristeleit
Jan 13, 2012·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Jan 16, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Shu-Dong YuQi-Rong Wang
Dec 3, 2013·Clinical Oncology : a Journal of the Royal College of Radiologists·A J ColeJ M O'Sullivan

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Citations

Oct 27, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xiao-Huang XuJin-Jian Lu
May 4, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Bo DengZhiqiang Cheng
Dec 5, 2019·The American Journal of Chinese Medicine·Han XiaoJunling Yang
Jun 7, 2017·Medicinal Research Reviews·Hong-Yi QiHui Ma
Jul 7, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ze-Yu ShiAlice Sze Tsai Wong
Feb 14, 2016·Journal of Experimental & Clinical Cancer Research : CR·Caixing SunShihua Wang
May 28, 2021·Frontiers in Oncology·Marike W van GisbergenLudwig J Dubois

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