PMID: 8950033Nov 1, 1996Paper

Ginsenoside-Rh1 and Rh2 inhibit the induction of nitric oxide synthesis in murine peritoneal macrophages

Biochemistry and Molecular Biology International
Y C ParkH D Kim

Abstract

The effects of ginsenoside-Rh1 and Rh2 in the induction of nitric oxide (NO) synthesis by IFN-gamma plus LPS were investigated using murine peritoneal macrophages. The NO production from rIFN gamma plus LPS-treated macrophages was markedly reduced by ginsenoside-Rh1 or Rh2 in a dose dependent manner, but had no inhibitory effects by ginsenoside-Rb1, Rc or Re. In addition, treatment of the cells with ginsenoside-Rh2 6 hr before the stimulation with IFN-gamma plus LPS showed more inhibitory effect than the treatment with ginsenoside-Rh2 6 hr after or simultaneously with the stimulation with IFN-gamma plus LPS in the NO production. Ginsenoside-Rh2 also effectively inhibited IFN-gamma induced NO production when the cells were treated with IFN-gamma 6 hr after the treatment with ginsenoside-Rh2. Our findings suggest that this phenomenon might be caused by inhibition of priming signal such as IFN-gamma for the synergistic induction of NO synthesis.

Citations

Aug 5, 2003·Pharmacology, Biochemistry, and Behavior·David O Kennedy, Andrew B Scholey
Dec 12, 2001·British Journal of Pharmacology·R FriedlP G Spieckermann
Mar 29, 2014·Nutrition Reviews·Imogen SmithBenjamin J Whalley
Nov 29, 2011·Journal of Pharmaceutical and Biomedical Analysis·Sa-Im LeeSeon-Pyo Hong

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