PMID: 25735339Mar 5, 2015Paper

Ginsenoside Rh2 differentially mediates microRNA expression to prevent chemoresistance of breast cancer

Asian Pacific Journal of Cancer Prevention : APJCP
Xu WenJinhai Tang

Abstract

Chemoresistance is the most common cause of chemotherapy failure during breast cancer (BCA) treatment. It is generally known that the mechanisms of chemoresistance in tumors involve multiple genes and multiple signaling pathways,; if appropriate drugs are used to regulate the mechanisms at the gene level, it should be possible to effectively reverse chemoresistance in BCA cells. It has been confirmed that chemoresistance in BCA cells could be reversed by ginsenoside Rh2 (G-Rh2). Preliminary studies of our group identified some drug- resistance specific miRNA. Accordingly, we proposed that G-Rh2 could mediate drug-resistance specific miRNA and corresponding target genes through the gene regulatory network; this could cut off the drug-resistance process in tumors and enhance treatment effects. G-Rh2 and breast cancer cells were used in our study. Through pharmaceutical interventions, we could explore how G-Rh2 could inhibit chemotherapy resistance in BCA, and analyze its impact on related miRNA and target genes. Finally, we will reveal the anti-resistance molecular mechanisms of G-Rh2 from a different angle in miRNA-mediated chemoresistance signals among cells.

References

Mar 5, 2011·Acta Pharmacologica Sinica·Nan WuHua Feng
Sep 29, 2011·Clinical Epigenetics·Kristy R KutanziIgor P Pogribny
Jan 21, 2012·Trends in Cell Biology·Xi ChenChen-Yu Zhang
Jun 30, 2012·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Jingwei ZhangGuangji Wang
Oct 23, 2012·Archives of Medical Research·Xiu-juan LiJin-hai Tang
Jul 28, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Yang-Chen LiuXin-En Huang
Aug 16, 2013·The Journal of Molecular Diagnostics : JMD·Nadine RatertKlaus Jung
Feb 27, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Jian-Ping GongDong-Feng Wang

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Citations

May 15, 2016·Acta Biochimica Et Biophysica Sinica·Jingjia HuangZhiyong Luo
Nov 6, 2018·Journal of Asian Natural Products Research·Wei-Wen ChenYing-Zi Zhuang
Oct 28, 2019·Current Topics in Medicinal Chemistry·Yu-Hang GuoYing Gao
Aug 26, 2020·Archives of Pharmacal Research·Yujin JinKyung-Sun Heo
Jun 4, 2018·Chinese Journal of Integrative Medicine·Huan-Dong ZhaoYu-Xiang Chen
Oct 2, 2020·Phytotherapy Research : PTR·Heng ZouZhongliang Ma

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