Ginsenosides from Korean red ginseng modulate T cell function via the regulation of NF-AT-mediated IL-2 production

Food Science and Biotechnology
Le Ba VinhYoung Ho Kim

Abstract

Korean red ginseng is a traditional health food frequently used to prevent or treat various diseases worldwide. In this study, we evaluated the immunomodulatory activities of eleven compounds (1-11) isolated from Korean red ginseng, focusing on T cell function. First, the effects of the eleven compounds were studied on the regulation of IL-2, a potent T cell growth factor. Compounds 5, 7, and 9 significantly increased IL-2 secretion in phorbol 12-myristate 13-acetate (PMA)/ionomycin (Io)-induced EL-4 T cells. Next, we examined the effects of compounds 5, 7, and 9 on the regulation of transcription factors related to IL-2 production in T cells. Compound 9 significantly increased the PMA/Io-induced promoter activity of nuclear factor of activated T cells (NF-AT) in EL-4 T cells, but did not have any significant effects on the promoters of NF- κB. These results suggest that compound 9 activates T cell function via the regulation of NF-AT-mediated IL-2 production.

References

Jun 1, 1992·Current Opinion in Immunology·K A Smith
Mar 20, 1999·Planta medica·L N AtopkinaP Potier
Nov 26, 1999·Biochemical Pharmacology·A S AtteleC S Yuan
Aug 30, 2001·Nature Immunology·K J Maloy, F Powrie
Oct 12, 2004·Cytokine·Sarah L Gaffen, Kathleen D Liu
Jun 2, 2005·Nature Reviews. Immunology·Fernando Macian
Jul 19, 2006·International Immunopharmacology·Jue-Hee Lee, Yongmoon Han
Aug 17, 2006·Cytokine & Growth Factor Reviews·Hyoung Pyo KimWarren J Leonard
Jun 23, 2009·Nature Reviews. Immunology·Yrina RochmanWarren J Leonard
May 30, 2013·Journal of Ginseng Research·Soowon Kang, Hyeyoung Min
Dec 3, 2013·The Journal of Clinical Investigation·Geok Choo SimLaszlo Radvanyi
Sep 10, 2014·Cytokine & Growth Factor Reviews·Geok Choo Sim, Laszlo Radvanyi
Jul 18, 2016·Experimental Hematology·Kaitlin A ReadKenneth J Oestreich
Feb 9, 2017·European Journal of Pharmacology·Jung Up ParkYoung Ran Kim
Oct 17, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zhansheng JiangXiubao Ren
Nov 5, 2017·Bioorganic & Medicinal Chemistry Letters·Le Ba VinhYoung Ho Kim
Feb 10, 2018·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Nazli Boke SarikahyaSuheyla Kirmizigul

❮ Previous
Next ❯

Citations

Feb 28, 2020·World Journal of Gastrointestinal Oncology·Wen-Qi CuiLi-Xuan Sang
Aug 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Le Ba VinhInkyu Hwang
Jan 14, 2021·Journal of Ginseng Research·Zubair Ahmed RatanJae Youl Cho

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.