GIP-like immunoreactivity in glucagon cells. Interactions between GIP and glucagon on insulin release

Acta Physiologica Scandinavica
B AhrénF Sundler

Abstract

In the present study the cellular and subcellular distribution of immunoreactive glucagon and GIP (gastric inhibitory polypeptide) were studied in the mouse. Furthermore, the effects of pure GIP and glucagon on basal and stimulated insulin secretion were investigated. Immunohistochemistry revealed that immunoreactive GIP occurred in the pancreatic glucagon cells and in endocrine cells, also displaying glucagon immunoreactivity, scattered along the small and large intestines. Electron immunocytochemistry revealed that the GIP-like material and glucagon coexisted in the secretory granules of the pancreatic glucagon cells. Pure porcine GIP and glucagon both stimulated basal insulin release. When equipotent doses of the peptides were given together, the two peptides antagonized each other's effect. Both peptides potentiated glucose- and carbachol-induced insulin release. When equipotent doses of the two peptides were given together prior to the administration of each of these secretagogues their effects on insulin release were additive.

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Citations

Jan 1, 1983·Journal of the Autonomic Nervous System·O H Viveros, S P Wilson
Jul 15, 2009·Trends in Endocrinology and Metabolism : TEM·Rhonda D Wideman, Timothy J Kieffer
Oct 1, 1986·General and Comparative Endocrinology·M E AbadJ H Rombout
May 19, 2007·Journal of Neuroscience Research·Jenny NybergPeter S Eriksson
Feb 1, 1986·Acta Pharmacologica Et Toxicologica·B AhrénI Lundquist
Aug 12, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·K FilipssonB Ahrén

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