GITR Blockade Facilitates Treg Mediated Allograft Survival.

Transplantation
Samsher B SonawaneJames F Markmann

Abstract

Many models of transplant tolerance have been found to depend on the induction of regulatory T cells (Tregs). Innate immune signals are known to suppress Tregs thereby augmenting immunity by abrogating Treg function. Such signals may also provide a barrier to transplantation tolerance mediated by Tregs. A number of cell surface molecules expressed by Tregs have been found to inhibit Treg activity, the best characterized of which is the glucocorticoid-induced tumor necrosis factor receptor-related (GITR) protein. By using an adoptive transfer model of allograft rejection, we can study the effects of inflammation and antigen-specific Tregs on graft survival. Inflammation resulting from the transplant procedure counter-regulates the suppressor activity of Tregs. To assess whether Treg activity could be enhanced by blocking GITR signaling, we compared the capacity of Tregs to prolong the survival of grafts in the presence or absence of activation-inducible TNF receptor (AITRL)-Fc, a novel construct that binds GITR. We report that interruption of GITR-GITR ligand (GITRL) binding by AITRL-Fc resulted in long-term Treg-dependent acceptance of skin grafts in the setting of innate immune signals that otherwise interfere with Treg activi...Continue Reading

References

Feb 12, 1993·Science·S QinH Waldmann
Dec 22, 1999·European Journal of Immunology·M S JordanA J Caton
Oct 25, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·L GracaH Waldmann
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·R S LeeJ C Madsen
Jan 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tim G A M WolfsCornelis van 't Veer
Nov 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Matthew A WilliamsChristian P Larsen
Jan 18, 2003·Science·Chandrashekhar Pasare, Ruslan Medzhitov
Feb 20, 2003·The Journal of Experimental Medicine·Iris CaramalhoJocelyne Demengeot
May 17, 2003·The Journal of Clinical Investigation·Daniel R GoldsteinFadi G Lakkis
Jul 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hugh M PatersonJames A Lederer
Nov 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·Masahide ToneHerman Waldmann
Mar 3, 2004·European Journal of Immunology·Simona RonchettiCarlo Riccardi
Apr 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Adam P KohmStephen D Miller
May 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Major K LeeJames F Markmann
Jul 14, 2004·The Journal of Experimental Medicine·Stephanie J MuriglanMarcel R M Van Den Brink
Oct 8, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Geoffrey L StephensEthan M Shevach
May 25, 2005·Transplantation·Byung Soo KimChul Woo Yang
Aug 27, 2005·Science·Guangyong PengRong-Fu Wang
Dec 13, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Natasha K CrellinMegan K Levings
Jan 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Thomas B ThornleyDale L Greiner
Jan 21, 2006·The Journal of Clinical Investigation·Roger P M SutmullerGosse J Adema
Feb 24, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shaoping DengJames F Markmann
Feb 24, 2006·Transplantation·Jagdeep Obhrai, Daniel R Goldstein
Mar 16, 2006·Blood·Xavier ValenciaPeter E Lipsky
May 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Teresa Ramirez-MontagutMarcel R M van den Brink
Jun 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Salvatore CuzzocreaCarlo Riccardi
Aug 15, 2006·Immunological Reviews·Herman WaldmannStephen Cobbold
Sep 15, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·L ChenA Chong
Nov 1, 2006·Critical Reviews in Immunology·Dieter KabelitzHans-Heinrich Oberg
Dec 1, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Salvatore CuzzocreaCarlo Riccardi
Dec 22, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Suigui WanLaurence Morel
Mar 30, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A Bushell, K Wood
Sep 7, 2007·Annals of the New York Academy of Sciences·Giuseppe NocentiniCarlo Riccardi
Jul 22, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Paige M PorrettLaurence A Turka

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Citations

Feb 4, 2014·Cytokine & Growth Factor Reviews·Derek L Clouthier, Tania H Watts
Jul 16, 2014·Clinics in Liver Disease·Paige M PorrettAbraham Shaked
Mar 12, 2013·Transplantation Reviews·Heidi YehJames I Kim
Oct 5, 2010·Immunology Letters·Simona RonchettiCarlo Riccardi
Dec 20, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·B E Burrell, J S Bromberg
Oct 28, 2011·British Journal of Pharmacology·Giuseppe NocentiniCarlo Riccardi
Feb 12, 2010·European Journal of Immunology·James I KimJames F Markmann
Mar 7, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S C JuvetK J Wood
Sep 16, 2010·International Reviews of Immunology·Adnan R KhanDavid I Pritchard
May 28, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Blair T StocksDaniel J Moore
Nov 7, 2019·Journal of Cellular Physiology·Alireza MardomiSaeid Abediankenari
Dec 14, 2019·Journal of Leukocyte Biology·Zhuo FuYu Zhang

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