"Give me five" ultra-hypofractionated radiotherapy for localized prostate cancer: non-invasive ablative approach

Medical Oncology
Giulia MarvasoBarbara A Jereczek-Fossa

Abstract

Ultra-hypofractionated radiotherapy (RT) is given over a shorter time with larger doses with respect to conventional fractionation in patients with localized prostate cancer (PCa). The use of hypofractionation is supported both from the radiobiological point of view (the low α/β-ratio in PCa and dose escalation) and from the rising number of clinical evidences. The aim of this study is to review our data regarding oncological outcomes, namely biochemical progression-free survival (b-PFS) and clinical progression-free survival (c-PFS), acute and long-term toxicities in patients treated with a ultra-hypofractionated RT. A series of 194 patients with clinically localized PCa treated primarily with ultra-hypofractionated RT using image-guided intensity modulated RT (IG-IMRT) at our Institute from 2012 to 2015 was included in this analysis. According to NCCN risk group classification, 65 (33.5%) patients were low risk, 101 (52.1%) intermediate risk, and 28 (14.4%) high risk. Androgen deprivation therapy (ADT) was given to 61 patients (31.4%). A 169 patients (87.1%) received 35 Gy in 5 fractions, while 25 patients (13%) received 32.5 Gy in 5 fractions (usually given in patients with comorbidity). The median duration of the treatment ...Continue Reading

References

Mar 30, 1995·International Journal of Radiation Oncology, Biology, Physics·J D CoxT F Pajak
Jan 5, 2002·International Journal of Radiation Oncology, Biology, Physics·David J BrennerElwood P Armour
Sep 4, 2007·International Journal of Radiation Oncology, Biology, Physics·Deborah A KubanAlan Pollack
Sep 17, 2009·Technology in Cancer Research & Treatment·Jay L FriedlandDavid M Spellberg
Dec 3, 2009·American Journal of Clinical Oncology·Alvaro A MartinezGary S Gustafson
Jan 5, 2011·Journal of Medical Imaging and Radiation Oncology·J M MartinP Chung
Feb 9, 2011·International Journal of Radiation Oncology, Biology, Physics·Christopher R KingJoseph C Presti
Feb 12, 2011·International Journal of Radiation Oncology, Biology, Physics·D Jeffrey DemanesGary Gustafson
Feb 25, 2011·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Bettina HentschelAnsgar Malich
Aug 2, 2011·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·V Grégoire, T R Mackie
Jul 5, 2012·Women's Health·Lydia E Pace, Eleanor Bimla Schwarz
Sep 26, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Christopher R KingAlan Katz
Nov 13, 2014·Frontiers in Oncology·Alan Jay Katz, Josephine Kang
Feb 25, 2015·Clinical Oncology : a Journal of the Royal College of Radiologists·D R HendersonN J van As
Jun 15, 2016·Nature Reviews. Urology·Stefano Arcangeli, Carlo Greco
Sep 15, 2016·The New England Journal of Medicine·J L DonovanUNKNOWN ProtecT Study Group*
Sep 16, 2016·Cancer Treatment Reviews·Berardino De BariUNKNOWN on the behalf of the Italian Association of Radiation Oncology (AIRO)
Mar 28, 2017·Current Oncology Reports·Linus C BenjaminDavid P Dearnaley
Mar 30, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Giorgio ArcangeliLidia Strigari
Oct 27, 2017·World Journal of Clinical Oncology·Yusef A SyedAnurag K Singh
Nov 22, 2017·Oncotarget·Stefano Arcangeli, Giorgio Arcangeli

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Citations

Sep 4, 2019·Medical Physics·Cielle CollinsMark Oldham
Aug 14, 2020·The British Journal of Radiology·Leif-Erik D SchumacherEric A Mellon
Aug 5, 2019·International Journal of Radiation Oncology, Biology, Physics·Giulia MarvasoBarbara A Jereczek-Fossa
Nov 14, 2020·International Journal of Molecular Sciences·Alice ZamagniAnna Tesei

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