GIV/Girdin promotes cell survival during endoplasmic reticulum stress

Molecular and Cellular Biochemistry
Peter NguyenDeepali Bhandari

Abstract

Endoplasmic reticulum (ER) stress is a form of cellular stress that is experienced by cells both under normal physiological conditions such as in professional secretory cells and disease states such as cancer, diabetes, and neurodegeneration. Upon facing ER stress, cells activate a conserved signaling pathway called the unfolded protein response (UPR) to restore normal function by halting general protein translation, upregulating expression of chaperones, and promoting ER-associated degradation. However, if the stress is overwhelming and cells are not able to recover within a reasonable time frame, the UPR ultimately commits cells to programmed cell death. How cells make this life-or-death decision remains an exciting yet poorly understood phenomenon. Here, we show that Gα-interacting vesicle-associated protein (GIV) aka Girdin plays an important role in promoting cell survival during ER stress. Cells lacking GIV are impaired in activating the pro-survival Akt pathway upon induction of ER stress. These cells also show enhanced levels of the pro-apoptotic transcription factor, CCAAT/enhancer binding protein homologous protein (CHOP) as compared to control cells. Due to decreased pro-survival signals and a concomitant increase in...Continue Reading

References

Oct 16, 2003·Molecular and Cellular Biology·Ann-Hwee LeeLaurie H Glimcher
Sep 8, 2004·Molecular Cell·Cole M HaynesAntony A Cooper
Oct 16, 2004·Science·Umut OzcanGökhan S Hotamisligil
Nov 9, 2004·Current Opinion in Cell Biology·Rammohan V Rao, Dale E Bredesen
Dec 18, 2004·Mutation Research·Martin Schröder, Randal J Kaufman
Sep 6, 2005·Developmental Cell·Atsushi EnomotoMasahide Takahashi
Oct 4, 2005·The Journal of Clinical Investigation·Chunyan XuJohn C Reed
Dec 27, 2005·Biochemical and Biophysical Research Communications·Kanae HyodaYasuyuki Nomura
Jan 7, 2006·Cell Death and Differentiation·J Wu, R J Kaufman
Sep 6, 2006·EMBO Reports·Eva SzegezdiAfshin Samali
Feb 10, 2007·The FEBS Journal·Hiderou Yoshida
Apr 17, 2007·Brain Research·Toru HosoiKoichiro Ozawa
Nov 17, 2007·Cancer Research·Michel MoennerEric Chevet
Jul 30, 2008·The Journal of Cell Biology·Pradipta GhoshMarilyn G Farquhar
Dec 2, 2008·Nature Reviews. Drug Discovery·Inki KimJohn C Reed
Feb 13, 2009·Proceedings of the National Academy of Sciences of the United States of America·Mikel Garcia-MarcosMarilyn G Farquhar
Oct 14, 2009·Proceedings of the National Academy of Sciences of the United States of America·Adam J Schindler, Randy Schekman
Nov 17, 2009·Journal of Molecular and Cellular Cardiology·Tetsuo Minamino, Masafumi Kitakaze
Feb 20, 2010·International Journal of Cell Biology·Afshin SamaliSanjeev Gupta
Jul 6, 2010·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Yidan LinLongqi Chen
Oct 27, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mikel Garcia-MarcosPradipta Ghosh
Dec 15, 2010·Current Opinion in Cell Biology·Gordon C ShoreScott A Oakes
Jan 27, 2011·Methods in Enzymology·Christine M Oslowski, Fumihiko Urano
Apr 28, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jessica MaiuoloNica Borgese
May 7, 2011·Cell Adhesion & Migration·Pradipta GhoshMarilyn G Farquhar

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BETA
protein folding
nucleotide exchange
electrophoresis
glycosylation

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