Giving form to the function of the heart: embedding cellular models in an anatomical framework

The Japanese Journal of Physiology
Nicolas Smith, P J Hunter

Abstract

A computational framework is presented for integrating the electrical, mechanical, and biochemical functions of the heart. The construction of efficient finite element representations of canine and porcine ventricular geometry and microstructure is outlined. Computational techniques are applied to solve large deformation soft tissue mechanics by using orthotropic constitutive laws for myocardial tissue and models of active tension generation embedded at the Gauss points in the finite element mesh. The reaction-diffusion equations governing electrical current flow in the heart are solved on a grid of deforming material points that access systems of ordinary differential equations representing the cellular processes underlying the cardiac action potential. Navier-Stokes equations are solved to predict coronary blood flow in a system of branching blood vessels embedded in the deforming myocardium.

References

Jan 1, 1997·Annals of Biomedical Engineering·C P BradleyP J Hunter
Oct 24, 1998·Progress in Biophysics and Molecular Biology·F J Vetter, A D McCulloch
Oct 24, 1998·Progress in Biophysics and Molecular Biology·P J HunterH E ter Keurs
Oct 24, 1998·Progress in Biophysics and Molecular Biology·F F Ch'enD Noble
Jan 25, 2000·Annals of Biomedical Engineering·N P SmithP J Hunter
Oct 4, 2000·Annals of Biomedical Engineering·C P BradleyP J Hunter
May 7, 2003·Progress in Biophysics and Molecular Biology·Carey Stevens, Peter J Hunter
Feb 6, 2004·Journal of Cardiovascular Electrophysiology·Nicolas P SmithAndrew J Pullan
May 15, 2004·Progress in Biophysics and Molecular Biology·Satoshi MatsuokaAkinori Noma
May 15, 2004·Progress in Biophysics and Molecular Biology·N P Smith, E J Crampin

❮ Previous
Next ❯

Citations

Nov 1, 2011·Expert Opinion on Medical Diagnostics·Iulia M GrafStanislav Emelianov
Oct 18, 2008·The Journal of Physiological Sciences : JPS·Takashi IjiriKazuo Nakazawa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved