gkmSVM: an R package for gapped-kmer SVM

Mahmoud GhandiMichael A Beer


We present a new R package for training gapped-kmer SVM classifiers for DNA and protein sequences. We describe an improved algorithm for kernel matrix calculation that speeds run time by about 2 to 5-fold over our original gkmSVM algorithm. This package supports several sequence kernels, including: gkmSVM, kmer-SVM, mismatch kernel and wildcard kernel. gkmSVM package is freely available through the Comprehensive R Archive Network (CRAN), for Linux, Mac OS and Windows platforms. The C ++ implementation is available at www.beerlab.org/gkmsvm mghandi@gmail.com or mbeer@jhu.edu Supplementary data are available at Bioinformatics online.


Mar 3, 2004·Bioinformatics·Christina S LeslieWilliam Stafford Noble
Aug 31, 2011·Genome Research·Dongwon LeeMichael A Beer
Jun 19, 2013·Nucleic Acids Research·Christopher Fletez-BrantMichael A Beer
Jul 19, 2013·Journal of Mathematical Biology·Mahmoud GhandiMichael A Beer
Jul 18, 2014·PLoS Computational Biology·Mahmoud GhandiMichael A Beer
Jun 16, 2015·Nature Genetics·Dongwon LeeMichael A Beer
Mar 8, 2016·ELife·Alisa MoJeremy Nathans
May 7, 2016·Bioinformatics·Dongwon Lee


Jan 26, 2017·Human Mutation·Michael A Beer
Aug 23, 2017·PLoS Computational Biology·Remo MontiLen A Pennacchio
Oct 31, 2018·Scientific Reports·Anand Pratap SinghSuraiya Jabin
Mar 19, 2020·Nucleic Acids Research·Tommaso AndreaniMiguel A Andrade-Navarro
Feb 28, 2020·Nature Communications·Naresh Doni JayaveluR David Hawkins
May 24, 2020·Annual Review of Genomics and Human Genetics·Michael A BeerDanwei Huangfu
Oct 17, 2018·Scientific Reports·Zhen ShenDe-Shuang Huang
Jul 31, 2020·Nature·E Christopher PartridgeEric M Mendenhall
Dec 23, 2017·Nucleic Acids Research·Raphaël Mourad, Olivier Cuvier
Dec 20, 2019·PLoS Computational Biology·Peter K Koo, Sean R Eddy
Sep 19, 2020·Nature Communications·Kushal K DeyAlkes L Price
Jun 14, 2017·Scientific Reports·Hongbo ZhangDe-Shuang Huang
Mar 17, 2018·Genome Biology·Raphaël MouradOlivier Cuvier
Jan 7, 2018·Genome Research·Hemangi G Chaudhari, Barak A Cohen
Nov 29, 2020·Science Advances·Jialin Liu, Marc Robinson-Rechavi
Dec 2, 2020·PloS One·Louisa-Marie KrützfeldtMartin Kircher
Dec 3, 2020·ELife·Nour J AbdulhayVijay Ramani
Jan 1, 2021·Bioinformatics·Derrick BlakelyYanjun Qi

Related Concepts

Computer Programs and Programming
Sequence Determinations, DNA
Sequence Analysis, Protein
Support Vector Machines
DNA Repair
Extracellular Matrix
Ras GTPase-Activating Proteins
Biological Neural Networks

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