Gla-rich protein is involved in the cross-talk between calcification and inflammation in osteoarthritis

Cellular and Molecular Life Sciences : CMLS
Sofia CavacoDina C Simes

Abstract

Osteoarthritis (OA) is a whole-joint disease characterized by articular cartilage loss, tissue inflammation, abnormal bone formation and extracellular matrix (ECM) mineralization. Disease-modifying treatments are not yet available and a better understanding of osteoarthritis pathophysiology should lead to the discovery of more effective treatments. Gla-rich protein (GRP) has been proposed to act as a mineralization inhibitor and was recently shown to be associated with OA in vivo. Here, we further investigated the association of GRP with OA mineralization-inflammation processes. Using a synoviocyte and chondrocyte OA cell system, we showed that GRP expression was up-regulated following cell differentiation throughout ECM calcification, and that inflammatory stimulation with IL-1β results in an increased expression of COX2 and MMP13 and up-regulation of GRP. Importantly, while treatment of articular cells with γ-carboxylated GRP inhibited ECM calcification, treatment with either GRP or GRP-coated basic calcium phosphate (BCP) crystals resulted in the down-regulation of inflammatory cytokines and mediators of inflammation, independently of its γ-carboxylation status. Our results strengthen the calcification inhibitory function of...Continue Reading

References

Mar 31, 2006·Arthritis and Rheumatism·Tuhina NeogiDavid T Felson
May 30, 2006·Osteoarthritis and Cartilage·J A Roman-Blas, S A Jimenez
Aug 15, 2006·Biochemical and Biophysical Research Communications·Sachie NakataniMasahiro Wada
Mar 22, 2007·Seminars in Dialysis·Rukshana C Shroff, Catherine M Shanahan
Jun 29, 2007·Thrombosis and Haemostasis·Ellen C M CranenburgCees Vermeer
Aug 21, 2007·Matrix Biology : Journal of the International Society for Matrix Biology·Andreas TagarielloAndreas Winterpacht
Nov 17, 2007·American Journal of Epidemiology·M Kyla SheaEmelia J Benjamin
Dec 25, 2007·The Journal of Biological Chemistry·Cordula Surmann-SchmittMichael Stock
Jun 13, 2009·Arthritis Research & Therapy·Steven B Abramson, Mukundan Attur
Aug 29, 2009·Arthritis and Rheumatism·M FuerstW Rüther
Sep 24, 2010·Arthritis and Rheumatism·Hang-Korng EaFrédéric Lioté
Dec 21, 2010·Current Opinion in Rheumatology·Ann K Rosenthal
May 19, 2011·Bioanalysis·Aaron Hernandez-SantanaGillian P McMahon
Aug 16, 2011·Matrix Biology : Journal of the International Society for Matrix Biology·Cristian Dan NeacsuAndreas Tagariello
Sep 20, 2011·Clinical Chemistry and Laboratory Medicine : CCLM·Ciprian N SilaghiAlexandra M Crăciun
Dec 14, 2011·Bone·Nicole EitzingerMichael Stock
Feb 16, 2013·The American Journal of Medicine·Devyani MisraTuhina Neogi
May 4, 2013·Therapeutic Advances in Musculoskeletal Disease·Jeremy Sokolove, Christin M Lepus
Jan 1, 2014·Reumatología clinica·Francisco J Blanco
Dec 30, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Carla S B ViegasDina C Simes
Jun 10, 2015·Bone·Meredith L ZochRyan C Riddle

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Citations

Jan 27, 2017·International Journal of Molecular Sciences·Eva Y G De VilderOlivier M Vanakker
Apr 21, 2018·Annals of Medicine·Ana Filipa GuedesNuno C Santos
Dec 21, 2019·Journal of Nephrology·Maria FusaroPascale Khairallah
Dec 12, 2017·Current Opinion in Rheumatology·Ann K Rosenthal
Mar 25, 2020·Biological Reviews of the Cambridge Philosophical Society·Jian-Fei YanKai Jiao
Mar 11, 2019·Aging·Carla S B Viegas, Dina C Simes
Apr 3, 2019·International Journal of Molecular Sciences·Ciprian N SilaghiAlexandra M Crăciun
Aug 28, 2019·International Journal of Molecular Sciences·Dina C SimesCatarina Marreiros
Apr 5, 2018·Frontiers in Bioengineering and Biotechnology·Ellen G J RipmeesterTim J M Welting
Aug 20, 2019·International Journal of Rheumatic Diseases·Hamza Malik OkuyanAydiner Kalaci
May 12, 2018·Molecular Medicine Reports·Lianpu WenShuzhuang Li
Jun 20, 2020·European Journal of Internal Medicine·Marco MariettaMario Luppi
Sep 3, 2021·Nutrition Reviews·Přemysl MladěnkaUNKNOWN OEMONOM researchers and collaborators

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