Glabridin, an isoflavan from licorice root, inhibits migration, invasion and angiogenesis of MDA-MB-231 human breast adenocarcinoma cells by inhibiting focal adhesion kinase/Rho signaling pathway

Molecular Nutrition & Food Research
Ya-Ling HsuPo-Lin Kuo

Abstract

In this study we first report the antimigration, antiinvasive effect of glabridin, a flavonoid obtained from licorice, in MDA-MB-231 human breast adenocarcinoma cells. Glabridin exhibited effective inhibition of cell metastasis by decreasing cancer cell migration and invasion of MDA-MB-231 cells. In addition, glabridin also blocked human umbilical vein endothelial cells (HUVEC) migration and decreased MDA-MB-231-mediated angiogenesis. Further investigation revealed that the inhibition of cancer angiogenesis by glabridin was also evident in a nude mice model. Blockade of MDA-MB-231 cells and HUVEC migration was associated with an increase of αγβ3 integrin proteosome degradation. Glabridin also decreased the active forms of FAK and Src, and enhanced levels of inactivated phosphorylated Src (Tyr 416), decreasing the interaction of FAK and Src. Inhibition of the FAK/Src complex by glabridin also blocked AKT and ERK1/2 activation, resulting in reduced activation of RhoA as well as myosin light chain phosphorylation. This study demonstrates that glabridin may be a novel anticancer agent for the treatment of breast cancer in three different ways: inhibition of migration, invasion and angiogenesis.

References

Jun 2, 1993·Journal of the National Cancer Institute·E J FeuerT Tong
Aug 23, 1996·The Journal of Biological Chemistry·M AmanoK Kaibuchi
Jun 29, 2000·Annual Review of Biochemistry·K KaibuchiM Amano
Jul 20, 2002·Life Sciences·Toshio FukaiTaro Nomura
Oct 3, 2002·Nature Reviews. Cancer·Robert Kerbel, Judah Folkman
Apr 19, 2003·The Journal of Biological Chemistry·Jinbin ZhaiDavid D Schlaepfer
May 12, 2005·Current Opinion in Immunology·Victor L J Tybulewicz
May 18, 2006·Molecular and Cellular Biology·Zhiping LiRichard G Pestell
Aug 22, 2006·Current Opinion in Cell Biology·Satyajit K Mitra, David D Schlaepfer
Jun 19, 2007·Cell·Daniel LiethaMichael J Eck
Jul 20, 2007·Journal of the American College of Nutrition·Fumiki AokiTatsumasa Mae
Oct 16, 2007·Journal of Nutritional Science and Vitaminology·Chinatsu ItoKazuki Kanazawa
Jan 22, 2008·Cancer Chemotherapy and Pharmacology·Tomohiro NabekuraShuji Kitagawa
Feb 19, 2008·Cancer Research·David SarrióJosé Palacios
May 20, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R S Finn
Jan 27, 2009·Cancer Metastasis Reviews·Jihe Zhao, Jun-Lin Guan
May 29, 2009·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Jun 13, 2009·International Journal of Cancer. Journal International Du Cancer·Vita M GolubovskayaWilliam G Cance
Nov 3, 2009·Journal of the National Cancer Institute·Charlie Schmidt
Jan 30, 2010·Cancer Metastasis Reviews·R Rathinam, Suresh K Alahari

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Citations

Jul 25, 2014·PloS One·Wei LiuYuan Ying Jiang
Mar 24, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Ming-Ju HsiehShun-Fa Yang
Jun 29, 2015·Free Radical Biology & Medicine·Vigyasa SinghMahendra P Darokar
Jul 16, 2013·Fitoterapia·Charlotte SimmlerShao-Nong Chen
Nov 12, 2014·Journal of Biomolecular Structure & Dynamics·Kavita Kumari Kakarala, Kaiser Jamil
Dec 24, 2013·Parasitology International·Harveer Singh CheemaMahendra P Darokar
Mar 21, 2015·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Qianyi LuZhi Zheng
Sep 10, 2016·Seminars in Cancer Biology·Prasad R DandawateShrikant Anant
Jun 5, 2012·Journal of Chromatographic Science·Y T KamalSayeed Ahmad
Dec 26, 2018·Natural Product Research·Deepak Singh KapkotiRajendra Singh Bhakuni
Aug 4, 2020·Journal of Experimental & Clinical Cancer Research : CR·Ming HongJinke Li
Nov 7, 2013·Acta Crystallographica. Section C, Crystal Structure Communications·Charlotte SimmlerBernard D Santarsiero
Apr 28, 2020·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Rama Rao MallaVenkata Ramesh Dasari
Mar 16, 2021·Phytotherapy Research : PTR·Lorena Cayetano-SalazarNapoleón Navarro-Tito
Jun 22, 2021·Current Drug Delivery·Mojdeh Rahnama GhahfarokhiBehrooz Movahedi

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