Glabridin, an isoflavan from licorice root, downregulates iNOS expression and activity under high-glucose stress and inflammation

Molecular Nutrition & Food Research
Itamar YehudaSnait Tamir

Abstract

In females, hyperglycemia abolishes estrogen-vascular protection, leading to inflammation and oxidative stress that are related to diabetes-associated cardiovascular complications. Such knowledge led us to examine the potential of glabridin, as a replacement of estrogen anti-inflammatory activity under high-glucose conditions. In macrophage-like cells, chronic glucose stress (28 and 44 mM) upregulated inducible nitric oxide synthase (iNOS) mRNA expression by 42 and 189%, respectively. Pretreatment with glabridin, under chronic glucose stress, downregulated the LPS-induced nitric oxide secretion and nitrotyrosine formation, by 39 and 21%, respectively. Pretreatment with estradiol did not prevent the LPS-induced nitrotyrosine formation. Furthermore, glabridin, brought about a decrease in the LPS-induced iNOS mRNA expression by 48%, as compared to cells pretreated with estradiol. Glabridin decreased protein levels of liver iNOS by 69% in adult mouse offspring which developed hyperglycemia after early fetal exposure to a saturated fatty acid-enriched maternal diet. Glabridin also decreased liver nitrotyrosine levels in offspring of regular diet-fed mothers after further receiving high-fat diet. Such results indicate that glabridin ...Continue Reading

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Citations

Mar 24, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Ming-Ju HsiehShun-Fa Yang
Nov 21, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ziyou WangZunnan Huang
Sep 22, 2016·Pharmaceutical Biology·Rui YangYing Liu
Jan 11, 2019·Chinese Medical Journal·Guo-Ming PangCheng Lu
Oct 11, 2019·International Journal of Molecular Sciences·Mohammad Hosein FarzaeiAnupam Bishayee
Feb 3, 2021·Journal of Microbiology and Biotechnology·Chijian ZhangTinggang He

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