Glandular lesions of the cervix. Validity of cytologic criteria used to differentiate reactive changes, glandular intraepithelial lesions and adenocarcinoma

Acta Cytologica
J P DiTomassoD R Mody

Abstract

To determine the validity and reproducibility of various cytologic criteria as discriminators between different glandular lesions of the cervix. Seventy-three cervicovaginal smears with glandular lesions and a documented histologic and/ or clinical correlation were studied. The lesions included reactive changes, low grade glandular intraepithelial lesion (LGIL) (encompassing endocervical glandular dysplasia), high grade glandular intraepithelial lesion (HGIL) (encompassing adenocarcinoma in situ) and invasive adenocarcinoma (IA). Twenty-three cytologic criteria were used to evaluate the smears, and the results were scored and statistically analyzed. Reactive lesions consistently showed well-defined cell borders, normal nuclear/cytoplasmic (N/C) ratio, minimal or absent nuclear overlapping, round to oval nuclei with fine chromatin and prominent nucleoli. HGIL (adenocarcinoma in situ) showed feathered edges, rosettes, cell strips, increased N/C ratio, elongated nuclei, marked nuclear overlapping and nuclei with hyperchromatic, coarse chromatin. IA shared features with HGIL but had a greater tendency to show a dirty background, single cells, mitotic figures, nuclear pleomorphism and large nucleoli. Logistic regression studies indi...Continue Reading

Citations

Oct 28, 1999·Cancer·D R Mody
May 23, 2000·Diagnostic Cytopathology·Z GhorabR Schinella
Jul 11, 2000·Diagnostic Cytopathology·S S Raab
Nov 5, 2003·Diagnostic Cytopathology·Joan F Cangiarella, David C Chhieng
Apr 2, 1998·Cytopathology : Official Journal of the British Society for Clinical Cytology·J P O'Sullivan
Apr 16, 1998·The American Journal of Surgical Pathology·C V Biscotti, W R Hart
Aug 18, 1999·Diagnostic Cytopathology·N J Mulvany, V Surtees
Jan 23, 2004·Archives of Pathology & Laboratory Medicine·Andrew A RenshawGeorge G Birdsong

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