Glandular (tubular and follicular) variants of medullary carcinoma of the thyroid

H R Harach, E D Williams


The original descriptions of medullary carcinoma stressed the lack of papillary and follicular differentiation and the presence of amyloid. During the last few years, the spectrum of histological features seen in tumours of C cell origin has broadened, and papillary and anaplastic forms have been reported. We have recently studied three cases of medullary carcinoma with a major 'tubular' or 'follicular' component, giving a microscopic picture suggestive of follicular carcinoma of the thyroid. These cases were studied with routine techniques, electron microscopy, and immunohistological methods using antibodies to calcitonin and thyroglobulin. In all three cases the calcitonin localization was positive, and apart from included peripheral thyroid follicles, the thyroglobulin was negative--even in the tumour with large follicles containing PAS positive colloid. In the cases with tubular lumina, electron microscopy showed a concentration of granules in the apical portion of the cells, with corresponding immunolocalization of calcitonin in a ring about the lumen. We conclude that medullary carcinoma should be considered in the differential diagnosis of every unusual thyroid carcinoma, even those showing glandular differentiation and ...Continue Reading


Nov 1, 1979·Cancer·G Bussolati, G Monga
Jul 1, 1976·Cancer·T NormannI O Brennhovd
May 1, 1970·American Journal of Clinical Pathology·A Polliack, U Freund
Nov 1, 1972·Acta Physiologica Scandinavica·A Hjalmarson, O Isaksson
Mar 1, 1966·Journal of Clinical Pathology·E D WilliamsI Doniach
Mar 1, 1966·Journal of Clinical Pathology·E D Williams
Nov 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·F SundlerT B Van Wimersma Greidanus
Aug 1, 1980·The American Journal of Surgical Pathology·G MendelsohnJ C Eggleston
Jan 1, 1959·The Journal of Clinical Endocrinology and Metabolism·J B HAZARDG CRILE

❮ Previous
Next ❯


Dec 1, 1990·Journal of Surgical Oncology·J A Van ZylD J Van Velden
Jul 31, 1989·Clinica Chimica Acta; International Journal of Clinical Chemistry·E KaiserW Worofka
May 1, 1995·Pathology, Research and Practice·G BussolatiA Pagani
Jan 1, 1991·Thyroid : Official Journal of the American Thyroid Association·M NoelM S Moukhtar
Jan 1, 1994·Thyroid : Official Journal of the American Thyroid Association·V A LiVolsi, S L Asa
Jan 1, 1990·Cytopathology : Official Journal of the British Society for Clinical Cytology·P ZeppaL Palombini
Jan 1, 1991·Cytopathology : Official Journal of the British Society for Clinical Cytology·M E MendonçaJ Soares
Sep 1, 1993·Histopathology·M Sobrinho-Simŏes
Jun 1, 1989·Acta Pathologica Japonica·N LertprasertsukeM Kubota
Feb 1, 1993·Journal of Clinical Pathology·H R Harach, U Bergholm
Dec 18, 2013·Endocrine Pathology·Xavier Matias-Guiu, Ronald De Lellis
Jan 1, 1986·Ultrastructural Pathology·J M NeslandJ V Johannessen
Jan 1, 1985·Ultrastructural Pathology·M A Sobrinho-SimõesJ V Johannessen
Jan 1, 1985·Ultrastructural Pathology·R HolmJ V Johannessen
Jan 1, 1985·Ultrastructural Pathology·M Sobrinho-SimõesJ V Johannessen
Jan 1, 1985·Ultrastructural Pathology·R GolouhV Eusebi
Dec 1, 1988·Pathology, Research and Practice·C SambadeM Sobrinho-Simões
Jun 4, 2010·Cytopathology : Official Journal of the British Society for Clinical Cytology·S KaushalR Ray
Jul 1, 1988·The Journal of Pathology·H R Harach
Jan 1, 1996·Clinical Oncology : a Journal of the Royal College of Radiologists·A M MoodyC L Harmer
Mar 15, 1989·Cancer·H Dominguez-MalagonJ Albores-Saavedra
Sep 1, 1991·Veterinary Pathology·B LeblancC Jobit
Jun 19, 2007·Cytopathology : Official Journal of the British Society for Clinical Cytology·M AronK Verma
Feb 2, 2011·Journal of Surgical Oncology·Ajit NambiarMoni Abraham Kuriakose
Sep 1, 1986·Veterinary Pathology·M A van der Velden, H Meulenaar
Apr 1, 1987·Scottish Medical Journal·A D BurtM K Browne
Mar 1, 1993·Endocrine Pathology·H Ruben Harach, Ulla Bergholm
Jul 8, 2020·Endocrine Pathology·José Manuel Cameselle-TeijeiroManuel Sobrinho-Simões
Mar 3, 2021·International Journal of Surgical Pathology·Jae Yeon SeokXuemo Fan
Mar 10, 2021·Endocrine Pathology·Virginia A Livolsi
Sep 24, 2015·Development·Ellen JohanssonMikael Nilsson

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.