PMID: 11917222Mar 28, 2002Paper

Glassy cell carcinoma of the uterine cervix: histochemical, immunohistochemical, and molecular genetic observations

International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
Noriko KatoTeiichi Motoyama

Abstract

Glassy cell carcinoma (GCC) of the uterine cervix is characterized by distinctive cytological features and an aggressive clinical course. Although this tumor has been usually considered a poorly differentiated variety of adenosquamous carcinoma (ASC), a clarification of the phenotype and histogenesis of GCC is still required. We examined three GCCs and four ASCs for histochemical and immunohistochemical phenotypes and molecular genetic status, comparing them with five nonkeratinizing squamous cell carcinomas and five endocervical-type mucinous adenocarcinomas. GCCs had a profile of cytokeratin expression similar to that of reserve cells or immature squamous cells of the cervix. In addition to squamous differentiation, GCCs sporadically produced intestinal-type mucin. HPV 18 was detected in two of three GCCs and two of four ASCs. GCCs may originate from multipotential stem or reserve cells that undergo early squamous differentiation. The presence of HPV 18 might stimulate biphasic squamous and glandular differentiation.

References

May 1, 1991·Japanese Journal of Cancer Research : Gann·H YoshikawaA Iwamoto
Jan 1, 1991·The American Journal of Surgical Pathology·M H StolerA N Walker
Jul 16, 1985·Biochemical and Biophysical Research Communications·S E GoelzB Vogelstein
Apr 1, 1997·Biology of Reproduction·I K GipsonJ A Hill
Jan 16, 1999·Gynecologic Oncology·I I WistubaA F Gazdar
Apr 27, 2000·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·M W JonesS D Finkelstein

❮ Previous
Next ❯

Citations

Jan 30, 2004·American Journal of Obstetrics and Gynecology·Michael P Hopkins, George W Morley
Apr 2, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Suzuko MoritaniSteven G Silverberg
Sep 18, 2010·The American Journal of Dermatopathology·Valentina CaputoFranco Rongioletti
Jun 2, 2009·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Sang-Kyum KimNam-Hoon Cho
Apr 1, 2014·Archives of Pathology & Laboratory Medicine·Joana Loureiro, Esther Oliva
Mar 1, 2011·Surgical Pathology Clinics·Kay J Park
May 6, 2014·European Journal of Obstetrics, Gynecology, and Reproductive Biology·A Zolciak-Siwinska, J Jonska-Gmyrek
Sep 28, 2018·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Simona StolnicuRobert A Soslow

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.