Glatiramer acetate blocks the activation of THP-1 cells by interferon-gamma

European Journal of Pharmacology
Q LiC T Bever

Abstract

Glatiramer acetate (previously known as copolymer 1) is a synthetic copolymer of four amino acids that has been approved for use in the treatment of multiple sclerosis. It has been shown to suppress myelin antigen specific T cell activation by competing with these antigens at the major histocompatibility complex class II binding site and by inducing antigen specific suppressor T cells. In this study we investigated the effects of glatiramer acetate on the human monocytic cell line, THP-1, activated by lipopolysaccharide and interferon-gamma as a model for macrophages. At non-toxic concentrations of glatiramer acetate there were dose dependent reductions in the percentage of cells expressing human leukocyte DR and DQ antigen as well as in mean fluorescence intensity by flow cytometry. Production of tumor necrosis factor-alpha and the lysosomal cysteine proteinase cathepsin B were markedly inhibited, but production of interleukin-1 increased. These results suggest that glatiramer acetate might alter macrophage effector function and suggest that further studies in human monocytes and macrophages are warranted.

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Citations

Nov 19, 2004·Journal of Neurology·Hans-Peter HartungYannis Zoukos
Oct 9, 2007·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Martin S WeberScott S Zamvil
Mar 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·Danielle BurgerPatrice H Lalive
Oct 19, 2013·Journal of Neuroinflammation·Madhan ThamilarasanUwe Klaus Zettl
Jul 24, 2007·Autoimmunity Reviews·Wiebke Schrempf, Tjalf Ziemssen
Jan 1, 2016·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·D S Kasatkin
Jun 24, 2017·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Michela SpadaroAntonio Bertolotto
Sep 8, 2017·Frontiers in Neurology·Maria BlondaCarlo Avolio
Jul 30, 2019·Frontiers in Immunology·Paulus S RommerOlaf Stuve
Jun 15, 2019·Cells·Frances K NallyClaire E McCoy

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