Glatiramer acetate immune system augmentation for peripheral nerve regeneration in rat crushed sciatic nerve model

The Journal of Bone and Joint Surgery. American Volume
Shai LuriaThomas E Trumble

Abstract

Protective antiself response to nervous system injury has been reported to be mediated by a T-cell subpopulation that can recognize self-antigens. Immune cells have been shown to play a role in the regulation of motor neuron survival after a peripheral nerve injury. The objective of the present study was to evaluate the effects of immune system augmentation with use of the antigen glatiramer acetate, which is known to affect T-cell immunity, on peripheral nerve regeneration. Wild-type and nude-type (T-cell-deficient) rats underwent crush injury of the sciatic nerve. Three and six weeks after the injury, the sciatic nerve was examined, both functionally (on the basis of footprint analysis and the tibialis anterior muscle response and weight) and histologically (on the basis of axon count). Significantly greater muscle responses were measured after three weeks in the group of wild-type rats that were treated with glatiramer acetate (control limb:injured limb ratio, 0.05 for the glatiramer acetate group [n = 9], compared with 0.51 for the saline solution group [n = 8]; p < 0.05). Higher axon counts were also found in this group (control limb:injured limb ratio, -0.07 for the glatiramer acetate group [n = 10], compared with 0.29 fo...Continue Reading

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Citations

Mar 25, 2011·British Medical Bulletin·Pilar Martínez de AlbornozNicola Maffulli
Jan 24, 2012·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·W Martin BauknightRaqeeb Haque
Jan 13, 2015·Revista española de cirugía ortopédica y traumatología·M Herrera-PérezJ L Pais-Brito
Jun 18, 2019·Drug Metabolism Reviews·Olimpiu Bota, Lucian Fodor

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