Glatiramer acetate-reactive T lymphocytes regulate oligodendrocyte progenitor cell number in vitro: role of IGF-2.

Journal of Neuroimmunology
Y ZhangG R John

Abstract

Glatiramer acetate (GA) is an immunomodulator approved for therapy of relapsing-remitting multiple sclerosis (RRMS), but recent findings indicate that it may also have additional, neurotrophic effects. Here, we found that supernatants from human GA-reactive T lymphocytes potentiated oligodendrocyte numbers in rodent and human oligodendrocyte progenitor (OPC) cultures. Effects of Th2-polarized lines were stronger than Th1-polarized cells. Microarray and ELISA analyses revealed that neurotrophic factors induced in Th2- and Th1-polarized GA-reactive lines included IGF-2 and BMP-7 respectively, and functional studies confirmed IGF-2 as trophic for OPCs. Our results support the concept that GA therapy may result in supportive effects on oligodendrocytes in RRMS patients.

References

Sep 1, 1992·Journal of Neuroscience Research·R S Vick, G H DeVries
Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·R AharoniR Arnon
Jan 29, 1998·The New England Journal of Medicine·B D TrappL Bö
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·M B EisenD Botstein
Jun 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·O NeuhausR Hohlfeld
Dec 13, 2000·Neurology·B GranR Martin
Dec 18, 2001·Journal of Neurobiology·G L Caporaso, M V Chao
Apr 18, 2002·Journal of Neuroimmunology·R S NicholasD A Compston
Jun 4, 2002·Nature Medicine·Helmut ButzkuevenTrevor J Kilpatrick
Feb 1, 2003·Journal of the Neurological Sciences·Wolfgang BrückChristine Stadelmann
May 6, 2003·Annals of Neurology·Allan J BieberMoses Rodriguez
Oct 22, 2003·Journal of the Neurological Sciences·Man ChenSuhayl Dhib-Jalbut
Jan 8, 2004·The Journal of Cell Biology·Jenny HsiehFred H Gage
Mar 30, 2004·Journal of Neuroscience Research·Robert H MillerAlison K Hall
Apr 20, 2004·Brain : a Journal of Neurology·Martin S WeberCinthia Farina
May 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ho Jin KimAmit Bar-Or
Sep 17, 2004·Proceedings of the National Academy of Sciences of the United States of America·Ruth Arnon, Rina Aharoni
Feb 9, 2005·Brain : a Journal of Neurology·A K Foote, W F Blakemore
Dec 21, 2005·Proceedings of the National Academy of Sciences of the United States of America·Rina AharoniRuth Arnon
Jan 4, 2006·Developmental Biology·Limin GaoRobert H Miller
Nov 24, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yueting ZhangGareth R John
Jul 17, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Y JeeT L Vollmer
Oct 9, 2007·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Martin S WeberScott S Zamvil
Apr 9, 2008·Journal of Neurology·François Blanchette, Oliver Neuhaus
Mar 7, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ana GadeaVittorio Gallo
Jun 24, 2008·Brain : a Journal of Neurology·H NeumannR J M Franklin
Oct 14, 2008·Neuroscience·M KerschensteinerR Hohlfeld
Oct 10, 2009·Proceedings of the National Academy of Sciences of the United States of America·Viktor SkiharV Wee Yong
Oct 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Yueting ZhangGareth R John

❮ Previous
Next ❯

Citations

Oct 17, 2012·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Michael B Keough, V Wee Yong
Aug 12, 2015·Seminars in Immunopathology·Luke M HealyJack P Antel
Feb 2, 2010·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Laureline BerthelotDavid-Axel Laplaud
Nov 12, 2016·Journal of Neuroimmunology·Rina AharoniRuth Arnon
Mar 16, 2019·Cellular & Molecular Immunology·Heather Y F YongV Wee Yong
May 1, 2015·Expert Review of Neurotherapeutics·Aaron L BosterYossi Gilgun-Sherki
Jun 18, 2020·International Journal of Molecular Sciences·Kim M A De Kleijn, Gerard J M Martens
Dec 17, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Craig S MooreAmit Bar-Or
Feb 13, 2021·International Journal of Molecular Sciences·Natalia BaulinaOlga Favorova

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes in Repair & Regeneration

Astrocytes are glial cells found within the CNS and are able to regenerate new neurons. They become activated during CNS injury and disease. The activation leads to the transcription of new genes and the repair and regeneration of neurons. Discover the latest research on astrocytes in repair and regeneration here.

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.