Glaucoma after Ocular Surgery or Trauma: The Role of Infiltrating Monocytes and Their Response to Cytokine Inhibitors.

The American Journal of Pathology
Xiaoniao ChenEleftherios I Paschalis

Abstract

Glaucoma is a frequent and devastating long-term complication following ocular trauma, including corneal surgery, open globe injury, chemical burn, and infection. Postevent inflammation and neuroglial remodeling play a key role in subsequent ganglion cell apoptosis and glaucoma. To this end, this study was designed to investigate the amplifying role of monocyte infiltration into the retina. By using three different ocular injury mouse models (corneal suture, penetrating keratoplasty, and globe injury) and monocyte fate mapping techniques, we show that ocular trauma or surgery can cause robust infiltration of bone marrow-derived monocytes into the retina and subsequent neuroinflammation by up-regulation of Tnf, Il1b, and Il6 mRNA within 24 hours. This is accompanied by ganglion cell apoptosis and neurodegeneration. Prompt inhibition of tumor necrosis factor-α or IL-1β markedly suppresses monocyte infiltration and ganglion cell loss. Thus, acute ocular injury (surgical or trauma) can lead to rapid neuroretinal inflammation and subsequent ganglion cell loss, the hallmark of glaucoma. Infiltrating monocytes play a central role in this process, likely amplifying the inflammatory cascade, aiding in the activation of retinal microglia...Continue Reading

References

May 15, 1989·American Journal of Ophthalmology·H A QuigleyW R Green
Jul 1, 1997·Current Eye Research·C SotozonoS Kinoshita
Apr 17, 1998·Ophthalmology·P A NetlandC H Dohlman
Jun 10, 1998·Ophthalmic Research·F MiyamotoS Kinoshita
Oct 18, 2000·Survey of Ophthalmology·R S Ayyala
Jan 22, 2002·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·R KuckelkornC Redbrake
Feb 5, 2003·Experimental Eye Research·Jun YamadaShigeru Kinoshita
Jun 20, 2006·Cornea·Julie H TsaiAnup K Khatana
Dec 8, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Toru NakazawaLarry I Benowitz
Mar 19, 2008·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Mona Harissi-Dagher, Claes H Dohlman
Apr 30, 2011·Physiological Reviews·Helmut KettenmannAlexei Verkhratsky
Oct 11, 2011·American Journal of Ophthalmology·Julia C TalajicMona Harissi-Dagher
Dec 3, 2011·Cornea·Roheena KamyarShahzad I Mian
Feb 9, 2012·Journal of Ophthalmology·Ammar M Al-MahmoodDeepak P Edward
Feb 4, 2014·Cornea·Fabiano CadeClaes H Dohlman
Aug 26, 2014·Investigative Ophthalmology & Visual Science·Giulio FerrariPaolo Rama
Oct 18, 2014·Seminars in Ophthalmology·Ramez I Haddadin, James Chodosh
Apr 8, 2016·Investigative Ophthalmology & Visual Science·Alja ČrnejReza Dana
Jan 24, 2017·Investigative Ophthalmology & Visual Science·Chengxin ZhouEleftherios I Paschalis
Apr 17, 2017·The American Journal of Pathology·Eleftherios I PaschalisClaes H Dohlman
Jun 22, 2017·Current Eye Research·Hosoon ChoiSamuel Fulcher
Oct 21, 2017·Investigative Ophthalmology & Visual Science·Sergio Groman-LupaJoseph A Brzezinski
Nov 15, 2017·Cornea·Claes H DohlmanEleftherios I Paschalis
Apr 10, 2018·The American Journal of Pathology·Eleftherios I PaschalisClaes H Dohlman
Nov 18, 2018·Proceedings of the National Academy of Sciences of the United States of America·Eleftherios I PaschalisClaes H Dohlman
Dec 14, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eleftherios I PaschalisClaes H Dohlman
Aug 28, 2019·Cornea·Claes H DohlmanEleftherios I Paschalis

❮ Previous
Next ❯

Citations

Nov 18, 2020·Translational Vision Science & Technology·Pui-Chuen HuiEleftherios I Paschalis
Apr 16, 2021·Investigative Ophthalmology & Visual Science·Dominique GeoffrionMona Harissi-Dagher
Jun 24, 2021·Investigative Ophthalmology & Visual Science·Zhixin JiangXuan Li
Jun 13, 2021·The Ocular Surface·Liqiang WangYifei Huang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

The Journal of Immunology : Official Journal of the American Association of Immunologists
Eleftherios I PaschalisClaes H Dohlman
BioRxiv : the Preprint Server for Biology
Eleftherios I PaschalisClaes H Dohlman
© 2021 Meta ULC. All rights reserved