Glaucoma Structural and Functional Progression in American and Korean Cohorts

Ophthalmology
Tigran KostanyanGadi Wollstein

Abstract

To compare the rate of glaucoma structural and functional progression in American and Korean cohorts. Retrospective longitudinal study. Three hundred thirteen eyes from 189 glaucoma and glaucoma suspects, followed up for an average of 38 months. All subjects were examined semiannually with visual field (VF) testing and spectral-domain optical coherence tomography. All subjects had 5 or more reliable visits. The rates of change of retinal nerve fiber layer (RNFL) thickness, cup-to-disc (C/D) ratios, and VF mean deviation (MD) were compared between the cohorts. Variables affecting the rate of change for each parameter were determined, including ethnicity, refraction, baseline age and disease severity, disease subtype (high- vs. normal-tension glaucoma), clinical diagnosis (glaucoma vs. glaucoma suspect), and the interactions between variables. The Korean cohort predominantly demonstrated normal-tension glaucoma, whereas the American cohort predominantly demonstrated high-tension glaucoma. Cohorts had similar VF parameters at baseline, but the Korean eyes had significantly thicker mean RNFL and larger cups. Korean glaucoma eyes showed a faster thinning of mean RNFL (mean, -0.71 μm/year vs. -0.24 μm/year; P < 0.01). There were no d...Continue Reading

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Citations

Apr 12, 2016·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Min Kyung SongJi Yun Lee
Apr 12, 2017·The British Journal of Ophthalmology·Junki KwonJi Min Park
Sep 7, 2018·Journal of Glaucoma·Reza AlizadehJoseph Caprioli
Apr 9, 2021·The British Journal of Ophthalmology·Fei LiLinda M Zangwill

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