PMID: 1151702Aug 1, 1975

GLC analysis of hydrochlorothiazide in blood and plasma

Journal of Pharmaceutical Sciences
W J VandenheuvelF J Wolf

Abstract

GLC with electron-capture detection was successfully applied to the analysis of hydrochlorothiazide in human blood and plasma with a sensitivity (0.05 mug/ml) suitable for use with persons on therapeutic dosage levels. On-column methylation with trimethylanilinium hydroxide in methanol was employed to convert hydrochlorothiazide and its bromo analog, which served as the internal standard, to their tetramethyl derivatives.

Citations

Jan 1, 1977·Journal of Clinical Pharmacology·G J YakatanJ T Doluisio
Jan 3, 1977·European Journal of Clinical Pharmacology·O BrorsE Arnesen
Jan 1, 1991·Journal of Pharmaceutical and Biomedical Analysis·F Y TsaiB Chang
Dec 1, 1994·Journal of Pharmaceutical and Biomedical Analysis·J Y HsiehM R Dobrinska
Mar 15, 2001·Journal of Pharmaceutical and Biomedical Analysis·M ZecevicD Minic
May 24, 2006·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Aleksandra ChmielewskaHenryk Lamparczyk
Feb 1, 1983·Journal of Pharmaceutical Sciences·S R Tamat, D E Moore
Nov 1, 1986·Biopharmaceutics & Drug Disposition·P G Welling
Jan 1, 1978·The Journal of International Medical Research·R LammintaustaR Mäntylä

Related Concepts

Chromatography, Gas-Liquid
Sectrazide

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.