PMID: 1151702Aug 1, 1975

GLC analysis of hydrochlorothiazide in blood and plasma

Journal of Pharmaceutical Sciences
W J VandenheuvelF J Wolf


GLC with electron-capture detection was successfully applied to the analysis of hydrochlorothiazide in human blood and plasma with a sensitivity (0.05 mug/ml) suitable for use with persons on therapeutic dosage levels. On-column methylation with trimethylanilinium hydroxide in methanol was employed to convert hydrochlorothiazide and its bromo analog, which served as the internal standard, to their tetramethyl derivatives.


Jan 1, 1977·Journal of Clinical Pharmacology·G J YakatanJ T Doluisio
Jan 3, 1977·European Journal of Clinical Pharmacology·O BrorsE Arnesen
Jan 1, 1991·Journal of Pharmaceutical and Biomedical Analysis·F Y TsaiB Chang
Dec 1, 1994·Journal of Pharmaceutical and Biomedical Analysis·J Y HsiehM R Dobrinska
Mar 15, 2001·Journal of Pharmaceutical and Biomedical Analysis·M ZecevicD Minic
May 24, 2006·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Aleksandra ChmielewskaHenryk Lamparczyk
Feb 1, 1983·Journal of Pharmaceutical Sciences·S R Tamat, D E Moore
Nov 1, 1986·Biopharmaceutics & Drug Disposition·P G Welling
Jan 1, 1978·The Journal of International Medical Research·R LammintaustaR Mäntylä

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