PMID: 1206490Dec 1, 1975Paper

GLC determination of procainamide in biological fluids

Journal of Pharmaceutical Sciences
K J Simons, R H Levy


A GLC method for the determination of procainamide in biological fluids is presented. By using a dipropyl analog of procainamide as an internal standard, both compounds can be chromatographed directly, yielding linear calibration curves and a sensitivity that allows quantitative determination of concentrations as low as 0.1 mug/ml. The extraction procedure was carefully modified to avoid hydrolysis of N-acetylprocainamide, a major metabolite of procainamide. The usefulness of the procedure is demonstrated by following the disappearance of procainamide from the plasma and urine of human subjects treated with the drug.


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Nov 1, 1974·Journal of Pharmaceutical Sciences·J SterlingW G Haney
Dec 1, 1973·European Journal of Clinical Pharmacology·E Karlsson
Dec 1, 1973·European Journal of Clinical Pharmacology·D FremstadK H Landmark
Feb 1, 1974·Journal of Pharmaceutical Sciences·L E Mather, G T Tucker
Aug 3, 1972·The New England Journal of Medicine·J Koch-Weser
Sep 1, 1972·Archives of Internal Medicine·H S Weily, E Genton
Mar 1, 1971·JAMA : the Journal of the American Medical Association·J Koch-Weser, S W Klein

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Aug 1, 1984·Journal of Pharmaceutical Sciences·J E Whitaker, A M Hoyt

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