PMID: 1206490Dec 1, 1975Paper

GLC determination of procainamide in biological fluids

Journal of Pharmaceutical Sciences
K J Simons, R H Levy

Abstract

A GLC method for the determination of procainamide in biological fluids is presented. By using a dipropyl analog of procainamide as an internal standard, both compounds can be chromatographed directly, yielding linear calibration curves and a sensitivity that allows quantitative determination of concentrations as low as 0.1 mug/ml. The extraction procedure was carefully modified to avoid hydrolysis of N-acetylprocainamide, a major metabolite of procainamide. The usefulness of the procedure is demonstrated by following the disappearance of procainamide from the plasma and urine of human subjects treated with the drug.

References

Mar 1, 1974·British Heart Journal·T R ShawJ Hamer
Nov 1, 1974·Journal of Pharmaceutical Sciences·J SterlingW G Haney
Dec 1, 1973·European Journal of Clinical Pharmacology·E Karlsson
Dec 1, 1973·European Journal of Clinical Pharmacology·D FremstadK H Landmark
Feb 1, 1974·Journal of Pharmaceutical Sciences·L E Mather, G T Tucker
Aug 3, 1972·The New England Journal of Medicine·J Koch-Weser
Sep 1, 1972·Archives of Internal Medicine·H S Weily, E Genton
Mar 1, 1971·JAMA : the Journal of the American Medical Association·J Koch-Weser, S W Klein

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Citations

Aug 1, 1984·Journal of Pharmaceutical Sciences·J E Whitaker, A M Hoyt

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