Gleason 7 prostate cancer treated with low-dose-rate brachytherapy: lack of impact of primary Gleason pattern on biochemical failure

BJU International
R G StockN N Stone

Abstract

What's known on the subject? and What does the study add? There appears to be a clear difference in cancer control outcomes for patients with Gleason scores of 3+4 and those with scores of 4+3 after radical prostatectomy. It has been documented that patients with Gleason 4+3 prostate cancer have higher incidences of non-organ-confined disease than those with primary pattern 3. Higher rates of extracapsular extension, seminal vesicle invasion and positive margins have been found to be associated with primary pattern 4 over 3. These higher rates of non-organ-confined disease can lead to increased biochemical failure, which, in turn, can lead to higher mortality rates. This study provides information on the prognostic significance of primary Gleason pattern in the brachytherapy management of prostate cancer. Study Type - Prognosis (case series) Level of Evidence 4. • To report the biochemical outcomes for Gleason 7 prostate cancer treated with brachytherapy. • To analyse the impact of the primary Gleason pattern as well as other disease- and treatment-related factors on outcome. • A total of 560 patients with Gleason 7 prostate cancer were treated between 1990 and 2008 with brachytherapy, alone or in combination with hormonal ther...Continue Reading

References

Apr 30, 1995·International Journal of Radiation Oncology, Biology, Physics·R G StockJ K DeWyngaert
Jul 20, 1999·The Journal of Urology·N N Stone, R G Stock
Oct 26, 2005·International Journal of Radiation Oncology, Biology, Physics·Richard G StockBarry S Rosenstein
Jun 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gregory P SwansonUNKNOWN SWOG 8794
Mar 18, 2009·International Journal of Radiation Oncology, Biology, Physics·Alice Y HoRichard G Stock
May 13, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jennifer R StarkLorelei A Mucci

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Citations

Dec 20, 2014·Journal of Magnetic Resonance Imaging : JMRI·Gheorghe IordanescuJennifer A Doll

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