Glecaprevir/pibrentasvir expands reach while reducing cost and duration of hepatitis C virus therapy.

Hepatology International
Ameer AbutalebEleanor Wilson

Abstract

Hepatitis C virus (HCV) treatments have dramatically progressed from poorly tolerated, moderately successful interferon-based therapies to highly effective all-oral interferon-free regimens. While sustained virologic responses have significantly improved with fixed-dose combinations (FDC) of these direct-acting antivirals (DAA), cost remains high and certain populations of patients remain difficult to treat. Glecaprevir (GLE, an NS3/4A protease inhibitor) and pibrentasvir (PIB, NS5A inhibitor) were recently approved as a FDC therapy for HCV, and have expanded reach, reduced cost, and in certain populations, reduced HCV treatment duration. GLE/PIB is effective across all genotypes, and has been shown to be effective in HIV-infected patients, patients with chronic kidney disease, and Child-Pugh A-compensated cirrhosis. GLE/PIB is also effective for a shortened duration of 8 weeks in treatment-naive non-cirrhotic patients.

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Citations

Sep 18, 2018·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Nicholas WetterstenSaima Aslam
Jun 25, 2020·Revista Da Sociedade Brasileira De Medicina Tropical·Vinicius Lins FerreiraRoberto Pontarolo
Sep 22, 2018·Hepatology International·Ameer Abutaleb, Kenneth E Sherman
Oct 6, 2019·Arab Journal of Gastroenterology : the Official Publication of the Pan-Arab Association of Gastroenterology·Mortada El-Shabrawi, Fetouh Hassanin
Sep 13, 2020·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Alessio AghemoUNKNOWN MARS Study Group
Oct 8, 2019·The Journal of Thoracic and Cardiovascular Surgery·Yasbanoo MoayediKiran K Khush

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